A0A267GMZ2 protein (Macrostomum lignano) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A267GMZ2

Protein kinase domain-containing protein. (567 aa)

Predicted Functional Partners:

A0A267GB57

0.949

A0A267H527

0.949

A0A267FBW1

0.940

A0A267EEI2

0.937

A0A267EFC6

0.937

A0A267G8J9

0.937

A0A267DSJ8

0.929

A0A267FYF3

0.929

A0A267FYH3

0.929

A0A1I8GV37

0.915

Your Current Organism:

Macrostomum lignano

NCBI taxonomy Id: 282301
Other names: M. lignano

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1I8GV37	A0A267DSJ8	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.472
A0A1I8GV37	A0A267EEI2	WD_REPEATS_REGION domain-containing protein.	Peptidase C50 domain-containing protein.	0.869
A0A1I8GV37	A0A267EFC6	WD_REPEATS_REGION domain-containing protein.	Peptidase C50 domain-containing protein.	0.869
A0A1I8GV37	A0A267FBW1	WD_REPEATS_REGION domain-containing protein.	HORMA domain-containing protein.	0.998
A0A1I8GV37	A0A267FYF3	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.472
A0A1I8GV37	A0A267FYH3	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.472
A0A1I8GV37	A0A267G8J9	WD_REPEATS_REGION domain-containing protein.	Peptidase C50 domain-containing protein.	0.869
A0A1I8GV37	A0A267GMZ2	WD_REPEATS_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.915
A0A267DSJ8	A0A1I8GV37	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.472
A0A267DSJ8	A0A267EEI2	Uncharacterized protein.	Peptidase C50 domain-containing protein.	0.949
A0A267DSJ8	A0A267EFC6	Uncharacterized protein.	Peptidase C50 domain-containing protein.	0.949
A0A267DSJ8	A0A267FBW1	Uncharacterized protein.	HORMA domain-containing protein.	0.442
A0A267DSJ8	A0A267G8J9	Uncharacterized protein.	Peptidase C50 domain-containing protein.	0.949
A0A267DSJ8	A0A267GB57	Uncharacterized protein.	Structural maintenance of chromosomes protein.	0.998
A0A267DSJ8	A0A267GMZ2	Uncharacterized protein.	Protein kinase domain-containing protein.	0.929
A0A267DSJ8	A0A267H527	Uncharacterized protein.	Structural maintenance of chromosomes protein.	0.998
A0A267EEI2	A0A1I8GV37	Peptidase C50 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.869
A0A267EEI2	A0A267DSJ8	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.949
A0A267EEI2	A0A267FBW1	Peptidase C50 domain-containing protein.	HORMA domain-containing protein.	0.884
A0A267EEI2	A0A267FYF3	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.949

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 553

0.96

1.13

4.11e-08

GO:0008643

Carbohydrate transport

3 of 41

1.53

0.75

0.0278

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015144

Carbohydrate transmembrane transporter activity

3 of 20

1.84

0.99

0.0114

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 922

0.6

0.4

0.0173

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7220

Mixed, incl. Bacterial extracellular solute-binding protein, and glycerol-3-phosphate transmembrane transporter activity

11 of 37

2.14

7.5

1.63e-20

CL:7222

Mixed, incl. glycerol-3-phosphate transmembrane transporter activity, and ABC-type carbohydrate transporter activity

10 of 28

2.22

7.42

8.63e-19

CL:7262

MalK, OB fold domain, and ABC-type carbohydrate transporter activity

6 of 8

2.54

5.59

8.74e-12

CL:7223

Mixed, incl. glycerol-3-phosphate transmembrane transporter activity, and ABC-type carbohydrate transporter activity

4 of 20

1.97

2.28

1.65e-05

CL:7247

Mixed, incl. glycerol-3-phosphate transmembrane transport, and ABC-type carbohydrate transporter activity

3 of 8

2.24

1.99

0.00015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 326

1.19

1.85

1.17e-11

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

7 of 68

1.68

2.86

1.21e-08

GOCC:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

3 of 19

1.86

1.69

0.00032

GOCC:1902517

glycerol-3-phosphate-transporting ATPase complex

2 of 3

2.49

1.6

0.0011

GOCC:0005886

Plasma membrane

10 of 723

0.81

1.68e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 279

1.17

1.56

6.24e-08

KW-1003

Cell membrane

7 of 329

0.99

0.94

0.00016

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

7 of 65

1.7

2.85

1.99e-08

PF13416

Bacterial extracellular solute-binding protein

3 of 15

1.97

1.35

0.0023

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

7 of 66

1.69

2.72

5.79e-08

IPR035906

MetI-like superfamily

7 of 67

1.68

2.71

5.79e-08

IPR006059

Bacterial extracellular solute-binding protein

3 of 16

1.94

1.19

0.0047

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About