node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOM00606.1 | AOM01147.1 | BFX80_03955 | BFX80_07320 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | 0.909 |
AOM00606.1 | AOM01614.1 | BFX80_03955 | BFX80_10330 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | 0.908 |
AOM00606.1 | fmt | BFX80_03955 | BFX80_02635 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.938 |
AOM00606.1 | folM | BFX80_03955 | BFX80_01730 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.903 |
AOM00606.1 | gcvT | BFX80_03955 | BFX80_11360 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.908 |
AOM00606.1 | glyA | BFX80_03955 | BFX80_04260 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
AOM00606.1 | glyA-2 | BFX80_03955 | BFX80_14915 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
AOM00606.1 | metH | BFX80_03955 | BFX80_08905 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.936 |
AOM00606.1 | purH | BFX80_03955 | BFX80_13125 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
AOM00606.1 | purN | BFX80_03955 | BFX80_05880 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.931 |
AOM01147.1 | AOM00606.1 | BFX80_07320 | BFX80_03955 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.909 |
AOM01147.1 | AOM01614.1 | BFX80_07320 | BFX80_10330 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | 0.923 |
AOM01147.1 | fmt | BFX80_07320 | BFX80_02635 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
AOM01147.1 | folM | BFX80_07320 | BFX80_01730 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.904 |
AOM01147.1 | gcvT | BFX80_07320 | BFX80_11360 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Glycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.923 |
AOM01147.1 | glyA | BFX80_07320 | BFX80_04260 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
AOM01147.1 | glyA-2 | BFX80_07320 | BFX80_14915 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
AOM01147.1 | metH | BFX80_07320 | BFX80_08905 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
AOM01147.1 | purH | BFX80_07320 | BFX80_13125 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.919 |
AOM01147.1 | purN | BFX80_07320 | BFX80_05880 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |