Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ARM77009.1Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (283 aa)    
Predicted Functional Partners:
ARM74799.1
2-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.998
ARM76056.1
Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.971
ARM74801.1
Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.964
sucD
succinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.938
ARM77184.1
succinate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.929
ARM74718.1
AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
ARM74723.1
AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
ARM74744.1
AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
ARM75440.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
ARM75548.1
AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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