Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadENAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (289 aa)    
Predicted Functional Partners:
ARM74989.1
Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.994
ARM75030.1
NAD(+) kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.962
ARM75523.1
Nicotinamide-nucleotide adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.939
ARM75865.1
Nicotinamide-nucleotide adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.939
cobB
NAD-dependent protein deacylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
    
 0.938
ARM74991.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.882
ARM76470.1
Nicotinate phosphoribosyltransferase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.824
ARM74874.1
Nicotinate-nucleotide diphosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
     
 0.623
nadA
Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
  
  
 0.609
ARM75703.1
biotin--[acetyl-CoA-carboxylase] ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.604
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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