Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ARM75520.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)    
Predicted Functional Partners:
ARM75518.1
3,4-dihydroxyphenylacetate 2,3-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.935
ARM75519.1
4-hydroxyphenylacetate 3-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.919
ARM74689.1
Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.786
ARM75517.1
Flavin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.618
ARM75546.1
Dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.494
ARM77080.1
Aldo/keto reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.483
fen
Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
   
 
 0.455
ARM74976.1
4a-hydroxytetrahydrobiopterin dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.436
ARM74834.1
Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.422
ARM75850.1
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.413
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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