Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (152 aa)    
Predicted Functional Partners:
ARM75820.1
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the formation of 3,4-dihydroxy 2-butanone 4-phosphate from ribulose 5-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
ARM75821.1
Riboflavin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.997
ARM75850.1
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.968
ARM75824.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.964
gch3
Hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
 
     0.960
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
  
 0.896
ARM77178.1
Cytidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.835
cbiX
Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily.
      
 0.818
pyrB
Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.817
rpl13
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
    0.789
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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