Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
tgtAtRNA guanosine(15) transglycosylase TgtA; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (494 aa)    
Predicted Functional Partners:
ARM75887.1
Sm ribonucleo; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.949
ARM75886.1
DNA-directed RNA polymerase subunit G; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.787
hisS
histidine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
  
 0.715
ychF
Redox-regulated ATPase YchF; The crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.696
ARM75828.1
tRNA pseudouridine(55) synthase TruB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.665
ARM75829.1
tRNA pseudouridine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.665
queE
Radical SAM protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
   
 0.660
ARM75111.1
6-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.653
ARM75140.1
2-methylthioadenine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.627
argS
arginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.624
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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