Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (390 aa)    
Predicted Functional Partners:
ARM75735.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.981
ARM75890.1
Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.947
ARM75889.1
Carboxylate--amine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.946
psmA
Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.944
rpl40e
50S ribosomal protein L40e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.931
psmB
Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.925
psmB-2
Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.925
ARM74622.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.914
ARM75892.1
TIGR00270 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.875
ARM75893.1
GTPase HflX; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.809
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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