ahcY protein (Acidianus manzaensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ahcY

Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (416 aa)

Predicted Functional Partners:

metE

0.973

ARM75815.1

0.972

ARM75149.1

0.954

ARM75717.1

0.941

ARM75894.1

0.918

ARM76241.1

0.854

ARM77109.1

0.841

thrB

0.826

ARM74667.1

0.800

glyA

0.774

Your Current Organism:

Acidianus manzaensis

NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARM74667.1	ARM75149.1	B6F84_00585	B6F84_03270	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ARM74667.1	ARM75815.1	B6F84_00585	B6F84_07035	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.800
ARM74667.1	ahcY	B6F84_00585	B6F84_08180	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.800
ARM74667.1	metE	B6F84_00585	B6F84_07030	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.	0.800
ARM75149.1	ARM74667.1	B6F84_03270	B6F84_00585	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ARM75149.1	ARM75815.1	B6F84_03270	B6F84_07035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.967
ARM75149.1	ARM76241.1	B6F84_03270	B6F84_09530	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
ARM75149.1	ARM77109.1	B6F84_03270	B6F84_07300	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.919
ARM75149.1	ahcY	B6F84_03270	B6F84_08180	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.954
ARM75149.1	glyA	B6F84_03270	B6F84_10970	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.574
ARM75149.1	metE	B6F84_03270	B6F84_07030	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.	0.966
ARM75149.1	thrB	B6F84_03270	B6F84_03275	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.994
ARM75717.1	ARM75894.1	B6F84_06470	B6F84_07515	N-ethylammeline chlorohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA (cytosine-5-)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.919
ARM75717.1	ahcY	B6F84_06470	B6F84_08180	N-ethylammeline chlorohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.941
ARM75815.1	ARM74667.1	B6F84_07035	B6F84_00585	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Selenium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.800
ARM75815.1	ARM75149.1	B6F84_07035	B6F84_03270	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.967
ARM75815.1	ARM76241.1	B6F84_07035	B6F84_09530	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
ARM75815.1	ARM77109.1	B6F84_07035	B6F84_07300	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.867
ARM75815.1	ahcY	B6F84_07035	B6F84_08180	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.972
ARM75815.1	glyA	B6F84_07035	B6F84_10970	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.611