Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (463 aa)    
Predicted Functional Partners:
cobD
CobD/CbiB family cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
 
 0.996
ARM74775.1
precorrin-3B C(17)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.994
cbiA
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.991
ARM77005.1
precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.976
ARM76102.1
Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.969
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.965
ARM76199.1
CoF synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.952
ARM74810.1
Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.949
ARM76220.1
adenosylcobinamide-GDP ribazoletransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.945
ARM74809.1
Precorrin-2 C(20)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family.
 
  
 0.935
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.