Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (192 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 
 0.999
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.997
pyrB
Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.996
ARM76281.1
2-polyprenylphenol hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.974
carB
Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family.
 
 
 0.965
pyrC
Dihydroorotase; Catalyzes the formation of dihydroorotate in the de novo pyrimidine biosynthetic pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.955
carA
Carbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family.
 
  
 0.947
ARM76276.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.947
ARM75367.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.920
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
 
 0.916
Your Current Organism:
Acidianus manzaensis
NCBI taxonomy Id: 282676
Other names: A. manzaensis, NBRC 100595, strain NA-1
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