ALS2 protein (Anolis carolinensis) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ALS2

Alsin Rho guanine nucleotide exchange factor ALS2. (1649 aa)

Predicted Functional Partners:

ZFAND4

0.963

RANBP2

0.784

GAPVD1

0.734

XPO1

0.724

XPO5

0.724

XPO6

0.724

ANKRD27

0.600

setx

0.595

ARHGEF16

0.578

GDI2

0.572

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS2	ANKRD27	ENSACAP00000000988	ENSACAP00000007329	Alsin Rho guanine nucleotide exchange factor ALS2.	Ankyrin repeat domain 27.	0.600
ALS2	ARHGEF16	ENSACAP00000000988	ENSACAP00000017488	Alsin Rho guanine nucleotide exchange factor ALS2.	Rho guanine nucleotide exchange factor 16.	0.578
ALS2	GAPVD1	ENSACAP00000000988	ENSACAP00000000558	Alsin Rho guanine nucleotide exchange factor ALS2.	GTPase activating protein and VPS9 domains 1.	0.734
ALS2	GDI2	ENSACAP00000000988	ENSACAP00000003049	Alsin Rho guanine nucleotide exchange factor ALS2.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.572
ALS2	RANBP2	ENSACAP00000000988	ENSACAP00000002048	Alsin Rho guanine nucleotide exchange factor ALS2.	RAN binding protein 2.	0.784
ALS2	XPO1	ENSACAP00000000988	ENSACAP00000002487	Alsin Rho guanine nucleotide exchange factor ALS2.	Exportin 1.	0.724
ALS2	XPO5	ENSACAP00000000988	ENSACAP00000009770	Alsin Rho guanine nucleotide exchange factor ALS2.	Exportin 5.	0.724
ALS2	XPO6	ENSACAP00000000988	ENSACAP00000016642	Alsin Rho guanine nucleotide exchange factor ALS2.	Exportin 6.	0.724
ALS2	ZFAND4	ENSACAP00000000988	ENSACAP00000007645	Alsin Rho guanine nucleotide exchange factor ALS2.	Zinc finger AN1-type containing 4.	0.963
ALS2	setx	ENSACAP00000000988	ENSACAP00000014063	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.595
ANKRD27	ALS2	ENSACAP00000007329	ENSACAP00000000988	Ankyrin repeat domain 27.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.600
ANKRD27	GDI2	ENSACAP00000007329	ENSACAP00000003049	Ankyrin repeat domain 27.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.541
ANKRD27	ZFAND4	ENSACAP00000007329	ENSACAP00000007645	Ankyrin repeat domain 27.	Zinc finger AN1-type containing 4.	0.577
ARHGEF16	ALS2	ENSACAP00000017488	ENSACAP00000000988	Rho guanine nucleotide exchange factor 16.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.578
GAPVD1	ALS2	ENSACAP00000000558	ENSACAP00000000988	GTPase activating protein and VPS9 domains 1.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.734
GAPVD1	GDI2	ENSACAP00000000558	ENSACAP00000003049	GTPase activating protein and VPS9 domains 1.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.541
GAPVD1	ZFAND4	ENSACAP00000000558	ENSACAP00000007645	GTPase activating protein and VPS9 domains 1.	Zinc finger AN1-type containing 4.	0.577
GDI2	ALS2	ENSACAP00000003049	ENSACAP00000000988	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.572
GDI2	ANKRD27	ENSACAP00000003049	ENSACAP00000007329	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	Ankyrin repeat domain 27.	0.541
GDI2	GAPVD1	ENSACAP00000003049	ENSACAP00000000558	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	GTPase activating protein and VPS9 domains 1.	0.541

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Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.857

expected number of edges:

6

PPI enrichment p-value:

0.0474

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018345

Protein palmitoylation

5 of 35

2.41

3.53

1.32e-07

GO:0018230

peptidyl-L-cysteine S-palmitoylation

4 of 24

2.48

2.81

4.59e-06

GO:0070200

Establishment of protein localization to telomere

2 of 5

2.86

1.29

0.0046

GO:0032202

Telomere assembly

2 of 5

2.86

1.29

0.0046

GO:0061820

Telomeric D-loop disassembly

2 of 7

2.71

1.23

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019706

Protein-cysteine S-palmitoyltransferase activity

3 of 29

2.27

1.45

0.0019

GO:0062037

D-loop DNA binding

2 of 5

2.86

1.36

0.0035

GO:0032357

Oxidized purine DNA binding

2 of 11

2.51

1.07

0.0110

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070187

Shelterin complex

2 of 7

2.71

1.0

0.0155

GO:0002178

Palmitoyltransferase complex

2 of 11

2.51

0.99

0.0155

GO:0000781

Chromosome, telomeric region

3 of 104

1.71

0.91

0.0155

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20205

peptidyl-L-cysteine S-palmitoylation, and Regulation of protein localization to phagocytic vesicle

5 of 12

2.87

5.0

4.84e-10

CL:20206

DHHC palmitoyltransferase

3 of 6

2.95

2.8

7.63e-06

CL:13601

Shelterin complex

2 of 5

2.86

1.35

0.0036

CL:20217

Mixed, incl. Golgin subfamily A member 7/ERF4 family, and Regulation of protein localization to phagocytic vesicle

2 of 6

2.78

1.31

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174437

Removal of the Flap Intermediate from the C-strand

3 of 18

2.48

1.9

0.00029

MAP-174414

Processive synthesis on the C-strand of the telomere

3 of 20

2.43

1.89

0.00029

MAP-174417

Telomere C-strand (Lagging Strand) Synthesis

3 of 37

2.16

1.64

0.00071

MAP-180786

Extension of Telomeres

3 of 64

1.92

1.31

0.0026

MAP-174430

Telomere C-strand synthesis initiation

2 of 14

2.41

1.1

0.0095

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002178

Palmitoyltransferase complex

2 of 10

2.55

0.81

0.0334

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 69

1.89

1.3

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01529

DHHC palmitoyltransferase

3 of 23

2.37

1.67

0.00075

PF10256

Golgin subfamily A member 7/ERF4 family

2 of 4

2.95

1.28

0.0048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001594

Palmitoyltransferase, DHHC domain

3 of 23

2.37

1.42

0.0023

IPR019383

Golgin subfamily A member 7/ERF4

2 of 4

2.95

1.01

0.0148

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