Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
tjp2Uncharacterized protein; Belongs to the MAGUK family. (1076 aa)    
Predicted Functional Partners:
TJP1
Tight junction protein 1; Belongs to the MAGUK family.
  
0.993
AFDN
Afadin, adherens junction formation factor.
   
 0.982
RAPGEF2
Rap guanine nucleotide exchange factor 2.
     
 0.913
NR1H4
Nuclear receptor subfamily 1 group H member 4.
      
 0.897
GJA1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 0.796
WWTR1
WW domain containing transcription regulator 1.
   
 0.789
YAP1
Yes associated protein 1.
   
 0.789
LOC100552932
CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.
     
 0.747
CLDN4
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 
 0.738
CLDN1
Claudin 1.
   
 
 0.719
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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