Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SERPINE1Serpin family E member 1; Belongs to the serpin family. (308 aa)    
Predicted Functional Partners:
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
   
 0.999
vtn
SMB domain-containing protein.
   
 0.995
plau
Uncharacterized protein.
   
 0.993
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
     
 0.927
LOC103279307
Uncharacterized protein.
   
 0.847
LOC103279306
Uncharacterized protein.
   
 0.847
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
    
 0.809
SRRT
Serrate, RNA effector molecule.
      
 0.782
GSTO1
Glutathione S-transferase omega 1; Belongs to the GST superfamily.
      
 0.725
GIGYF1
GRB10 interacting GYF protein 1.
      
 0.711
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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