STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GEN1GEN1 Holliday junction 5' flap endonuclease. (933 aa)    
Predicted Functional Partners:
WRN
WRN RecQ like helicase.
  
 0.994
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.897
FANCM
FA complementation group M.
   
 0.837
DNA2
DNA replication helicase/nuclease 2.
   
 0.835
MRE11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.802
GTF2H1
General transcription factor IIH subunit 1.
    
 0.778
POLD2
DNA polymerase delta 2, accessory subunit.
   
 0.771
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
   
 0.769
EME1
Essential meiotic structure-specific endonuclease 1.
   
 0.729
rmi2
Uncharacterized protein.
   
 
 0.728
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.