Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
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[Homology]
Score
MAPK11Mitogen-activated protein kinase. (361 aa)    
Predicted Functional Partners:
MAPKAPK2
MAPK activated protein kinase 2; Belongs to the protein kinase superfamily.
  
0.996
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
  
0.989
MAP2K3
Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.
  
0.984
map2k6
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
0.984
PTPRR
Protein tyrosine phosphatase receptor type R.
    
 0.980
MAPKAPK5
MAPK activated protein kinase 5.
   
0.978
ATF2
Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.
    
 0.978
MEF2C
Myocyte enhancer factor 2C.
    
 0.977
RPS6KA5
Ribosomal protein S6 kinase.
   
 
0.976
RPS6KA4
Ribosomal protein S6 kinase.
   
 
0.976
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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