Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PASKPAS domain containing serine/threonine kinase. (1189 aa)    
Predicted Functional Partners:
UGP2
UTP--glucose-1-phosphate uridylyltransferase.
   
 
 0.832
ppp1r7
LRRcap domain-containing protein.
    
 0.731
UCK2
Uridine-cytidine kinase 2.
    
 0.713
cmya5
Uncharacterized protein.
    
 0.705
ptprj
Uncharacterized protein.
    
 0.625
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
  0.614
PTPRZ1
Protein tyrosine phosphatase receptor type Z1.
    
 0.598
ADK
Adenosine kinase.
     
 0.524
SLC12A9
Solute carrier family 12 member 9.
    
 0.505
LOC100565784
Uncharacterized protein.
    
 0.505
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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