STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK12Mitogen-activated protein kinase. (361 aa)    
Predicted Functional Partners:
MAPKAPK2
MAPK activated protein kinase 2; Belongs to the protein kinase superfamily.
  
 
0.988
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
  
 
0.981
MAP2K3
Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.
  
0.974
map2k6
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
0.974
MAPKAPK5
MAPK activated protein kinase 5.
   
0.966
ATF2
Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.
    
 0.964
CDC42
Uncharacterized protein.
   
 0.961
PTPN7
Protein tyrosine phosphatase non-receptor type 7.
    
 0.950
JUN
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
    
 0.950
PTPRR
Protein tyrosine phosphatase receptor type R.
    
 0.950
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.