Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NRASNRAS proto-oncogene, GTPase. (194 aa)    
Predicted Functional Partners:
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
   
 0.985
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.979
RASA1
RAS p21 protein activator 1.
   
 0.975
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
    
 0.972
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.972
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
   
 0.965
KIT
KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.961
RASSF5
Ras association domain family member 5.
    
 0.950
RAPGEF2
Rap guanine nucleotide exchange factor 2.
    
 0.950
RASA2
RAS p21 protein activator 2.
    
 0.946
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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