RFC3 protein (Anolis carolinensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

RFC3

Replication factor C subunit 3. (356 aa)

Predicted Functional Partners:

PCNA

0.999

RFC2

0.999

RFC1

0.999

RFC4

0.999

RAD17

0.999

RFC5

0.999

ATAD5

0.989

CHTF18

0.988

DSCC1

0.986

hus1

0.982

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CHTF18	ENSACAP00000019218	ENSACAP00000008896	ATPase family AAA domain containing 5.	Chromosome transmission fidelity factor 18.	0.891
ATAD5	DSCC1	ENSACAP00000019218	ENSACAP00000008811	ATPase family AAA domain containing 5.	DNA replication and sister chromatid cohesion 1.	0.861
ATAD5	PCNA	ENSACAP00000019218	ENSACAP00000000398	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.977
ATAD5	RAD17	ENSACAP00000019218	ENSACAP00000010113	ATPase family AAA domain containing 5.	RAD17 checkpoint clamp loader component.	0.937
ATAD5	RFC1	ENSACAP00000019218	ENSACAP00000007449	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.699
ATAD5	RFC2	ENSACAP00000019218	ENSACAP00000000697	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.981
ATAD5	RFC3	ENSACAP00000019218	ENSACAP00000003823	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.989
ATAD5	RFC4	ENSACAP00000019218	ENSACAP00000007507	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.989
ATAD5	RFC5	ENSACAP00000019218	ENSACAP00000016376	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.986
ATAD5	hus1	ENSACAP00000019218	ENSACAP00000007963	ATPase family AAA domain containing 5.	Checkpoint protein; Belongs to the HUS1 family.	0.561
CHTF18	ATAD5	ENSACAP00000008896	ENSACAP00000019218	Chromosome transmission fidelity factor 18.	ATPase family AAA domain containing 5.	0.891
CHTF18	DSCC1	ENSACAP00000008896	ENSACAP00000008811	Chromosome transmission fidelity factor 18.	DNA replication and sister chromatid cohesion 1.	0.999
CHTF18	PCNA	ENSACAP00000008896	ENSACAP00000000398	Chromosome transmission fidelity factor 18.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.944
CHTF18	RAD17	ENSACAP00000008896	ENSACAP00000010113	Chromosome transmission fidelity factor 18.	RAD17 checkpoint clamp loader component.	0.901
CHTF18	RFC1	ENSACAP00000008896	ENSACAP00000007449	Chromosome transmission fidelity factor 18.	Replication factor C subunit 1.	0.845
CHTF18	RFC2	ENSACAP00000008896	ENSACAP00000000697	Chromosome transmission fidelity factor 18.	Replication factor C subunit 2.	0.987
CHTF18	RFC3	ENSACAP00000008896	ENSACAP00000003823	Chromosome transmission fidelity factor 18.	Replication factor C subunit 3.	0.988
CHTF18	RFC4	ENSACAP00000008896	ENSACAP00000007507	Chromosome transmission fidelity factor 18.	Replication factor C subunit 4.	0.986
CHTF18	RFC5	ENSACAP00000008896	ENSACAP00000016376	Chromosome transmission fidelity factor 18.	Replication factor C subunit 5.	0.989
CHTF18	hus1	ENSACAP00000008896	ENSACAP00000007963	Chromosome transmission fidelity factor 18.	Checkpoint protein; Belongs to the HUS1 family.	0.539

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.745

expected number of edges:

28

PPI enrichment p-value:

0.147

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990544

Mitochondrial ATP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:0140021

Mitochondrial ADP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:1901029

Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

3 of 11

2.65

2.02

0.00019

GO:1901526

Positive regulation of mitophagy

2 of 9

2.56

1.06

0.0116

GO:1990845

Adaptive thermogenesis

2 of 21

2.19

0.8

0.0340

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005471

ATP:ADP antiporter activity

3 of 4

3.09

2.6

1.90e-05

GO:0017077

Oxidative phosphorylation uncoupler activity

2 of 5

2.82

1.51

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005757

Mitochondrial permeability transition pore complex

3 of 10

2.69

2.22

8.08e-05

GO:0005815

Microtubule organizing center

6 of 749

1.12

0.96

0.0010

GO:0015630

Microtubule cytoskeleton

7 of 1238

0.97

0.81

0.0010

GO:0005814

Centriole

3 of 145

1.53

0.81

0.0204

GO:0005740

Mitochondrial envelope

5 of 641

1.11

0.77

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13605

Mitochondrial permeability transition pore complex, and TspO/MBR-related protein

3 of 13

2.58

1.87

0.00036

CL:12648

Post-chaperonin tubulin folding pathway, and Trafficking of myristoylated proteins to the cilium

3 of 13

2.58

1.87

0.00036

CL:13609

Mitochondrial permeability transition pore complex, and Porin, eukaryotic type

2 of 7

2.67

1.16

0.0078

CL:2389

Mixed, incl. Axonemal microtubule, and Tubulin/FtsZ, 2-layer sandwich domain

3 of 103

1.68

0.88

0.0172

CL:2422

Axonemal microtubule, and DM10 domain

2 of 22

2.17

0.84

0.0272

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 140

1.55

0.77

0.0265

map05017

Spinocerebellar ataxia

3 of 155

1.5

0.76

0.0265

map04218

Cellular senescence

3 of 188

1.42

0.74

0.0265

map04217

Necroptosis

3 of 180

1.44

0.74

0.0265

map04022

cGMP-PKG signaling pathway

3 of 179

1.44

0.74

0.0265

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-83936

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

5 of 13

2.8

4.99

4.15e-10

MAP-425397

Transport of vitamins, nucleosides, and related molecules

5 of 52

2.2

3.41

1.00e-07

MAP-425407

SLC-mediated transmembrane transport

5 of 309

1.43

1.35

0.00037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005757

Mitochondrial permeability transition pore complex

3 of 5

2.99

2.61

1.79e-05

GOCC:0005740

Mitochondrial envelope

5 of 418

1.29

1.05

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00153

Mitochondrial carrier protein

3 of 51

1.99

1.08

0.0086

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007714

CFA20 domain

3 of 3

3.22

2.57

2.25e-05

IPR002113

ADP/ATP carrier protein, eukaryotic type

3 of 3

3.22

2.57

2.25e-05

IPR002067

Mitochondrial carrier protein

3 of 27

2.26

1.5

0.0015

IPR044612

ADP-ribosylation factor-like protein 2/3

2 of 2

3.22

1.37

0.0034

IPR040441

Cilia- and flagella-associated protein 20/CFAP20DC

2 of 2

3.22

1.37

0.0034

(more ...)

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