node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFMID | KHK | ENSACAP00000016446 | ENSACAP00000011865 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Ketohexokinase. | 0.578 |
AFMID | KMO | ENSACAP00000016446 | ENSACAP00000009283 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.974 |
AFMID | PEMT | ENSACAP00000016446 | ENSACAP00000004425 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.587 |
AFMID | RPS24 | ENSACAP00000016446 | ENSACAP00000007801 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.565 |
CEPT1 | PCYT2 | ENSACAP00000004503 | ENSACAP00000010315 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphate cytidylyltransferase 2, ethanolamine. | 0.974 |
CEPT1 | PEMT | ENSACAP00000004503 | ENSACAP00000004425 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.687 |
CEPT1 | PISD | ENSACAP00000004503 | ENSACAP00000002732 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase. | 0.948 |
CHPT1 | PCYT2 | ENSACAP00000016371 | ENSACAP00000010315 | Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphate cytidylyltransferase 2, ethanolamine. | 0.750 |
CHPT1 | PEMT | ENSACAP00000016371 | ENSACAP00000004425 | Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.561 |
CHPT1 | PISD | ENSACAP00000016371 | ENSACAP00000002732 | Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase. | 0.503 |
GAMT | PEMT | ENSACAP00000005269 | ENSACAP00000004425 | Guanidinoacetate N-methyltransferase. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.658 |
ISYNA1 | PEMT | ENSACAP00000010555 | ENSACAP00000004425 | Inositol-3-phosphate synthase 1. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.613 |
KHK | AFMID | ENSACAP00000011865 | ENSACAP00000016446 | Ketohexokinase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.578 |
KHK | PEMT | ENSACAP00000011865 | ENSACAP00000004425 | Ketohexokinase. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.593 |
KHK | RPS24 | ENSACAP00000011865 | ENSACAP00000007801 | Ketohexokinase. | 40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.561 |
KMO | AFMID | ENSACAP00000009283 | ENSACAP00000016446 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.974 |
KMO | PEMT | ENSACAP00000009283 | ENSACAP00000004425 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.561 |
KMO | PISD | ENSACAP00000009283 | ENSACAP00000002732 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | Phosphatidylserine decarboxylase. | 0.661 |
PCYT2 | CEPT1 | ENSACAP00000010315 | ENSACAP00000004503 | Phosphate cytidylyltransferase 2, ethanolamine. | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.974 |
PCYT2 | CHPT1 | ENSACAP00000010315 | ENSACAP00000016371 | Phosphate cytidylyltransferase 2, ethanolamine. | Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.750 |