LOC100553870 protein (Anolis carolinensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

LOC100553870

Histone H4. (103 aa)

Predicted Functional Partners:

LOC100567871

0.818

ARID4B

0.771

ARID4A

0.771

HAT1

0.768

MYSM1

0.766

h3f3a

0.765

LOC100557439

0.762

LOC100555692

0.762

LOC100561045

0.762

H9GPZ8_ANOCA

0.761

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSACAP00000014391	ENSACAP00000001348	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.808
ARID4A	H9GPZ8_ANOCA	ENSACAP00000014391	ENSACAP00000017755	AT-rich interaction domain 4A.	Histone H3; Belongs to the histone H3 family.	0.773
ARID4A	LOC100553870	ENSACAP00000014391	ENSACAP00000004566	AT-rich interaction domain 4A.	Histone H4.	0.771
ARID4A	LOC100555692	ENSACAP00000014391	ENSACAP00000003271	AT-rich interaction domain 4A.	Histone H3.	0.773
ARID4A	LOC100557439	ENSACAP00000014391	ENSACAP00000003255	AT-rich interaction domain 4A.	Histone H3; Belongs to the histone H3 family.	0.773
ARID4A	LOC100561045	ENSACAP00000014391	ENSACAP00000010511	AT-rich interaction domain 4A.	Histone H3.	0.773
ARID4A	LOC100567871	ENSACAP00000014391	ENSACAP00000021479	AT-rich interaction domain 4A.	Histone H3.	0.773
ARID4A	MYSM1	ENSACAP00000014391	ENSACAP00000005394	AT-rich interaction domain 4A.	Myb like, SWIRM and MPN domains 1.	0.705
ARID4A	h3f3a	ENSACAP00000014391	ENSACAP00000005900	AT-rich interaction domain 4A.	Histone H3; Belongs to the histone H3 family.	0.773
ARID4B	ARID4A	ENSACAP00000001348	ENSACAP00000014391	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.808
ARID4B	H9GPZ8_ANOCA	ENSACAP00000001348	ENSACAP00000017755	AT-rich interaction domain 4B.	Histone H3; Belongs to the histone H3 family.	0.773
ARID4B	LOC100553870	ENSACAP00000001348	ENSACAP00000004566	AT-rich interaction domain 4B.	Histone H4.	0.771
ARID4B	LOC100555692	ENSACAP00000001348	ENSACAP00000003271	AT-rich interaction domain 4B.	Histone H3.	0.773
ARID4B	LOC100557439	ENSACAP00000001348	ENSACAP00000003255	AT-rich interaction domain 4B.	Histone H3; Belongs to the histone H3 family.	0.773
ARID4B	LOC100561045	ENSACAP00000001348	ENSACAP00000010511	AT-rich interaction domain 4B.	Histone H3.	0.773
ARID4B	LOC100567871	ENSACAP00000001348	ENSACAP00000021479	AT-rich interaction domain 4B.	Histone H3.	0.773
ARID4B	MYSM1	ENSACAP00000001348	ENSACAP00000005394	AT-rich interaction domain 4B.	Myb like, SWIRM and MPN domains 1.	0.713
ARID4B	h3f3a	ENSACAP00000001348	ENSACAP00000005900	AT-rich interaction domain 4B.	Histone H3; Belongs to the histone H3 family.	0.773
H9GPZ8_ANOCA	ARID4A	ENSACAP00000017755	ENSACAP00000014391	Histone H3; Belongs to the histone H3 family.	AT-rich interaction domain 4A.	0.773
H9GPZ8_ANOCA	ARID4B	ENSACAP00000017755	ENSACAP00000001348	Histone H3; Belongs to the histone H3 family.	AT-rich interaction domain 4B.	0.773

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.721

expected number of edges:

27

PPI enrichment p-value:

0.073

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050794

Regulation of cellular process

7 of 696

0.96

0.74

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4762

Cyclic nucleotide-binding domain, and Adenylate cyclase activity

5 of 14

2.51

4.1

1.17e-08

CL:4765

Cyclic nucleotide-binding domain

4 of 6

2.78

3.67

1.51e-07

CL:4182

PAS-associated, C-terminal, and Adenylyl cyclase class-3/4/guanylyl cyclase

3 of 45

1.78

1.01

0.0101

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02024

Quorum sensing

4 of 204

1.25

0.94

0.0036

map02020

Two-component system

6 of 592

0.96

0.76

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

4 of 18

2.3

2.54

1.24e-05

IPR018490

Cyclic nucleotide-binding domain superfamily

4 of 23

2.2

2.45

1.48e-05

IPR014710

RmlC-like jelly roll fold

4 of 42

1.94

1.96

9.10e-05

IPR012318

Crp-type HTH domain

2 of 9

2.3

0.81

0.0324

IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase

2 of 13

2.14

0.71

0.0494

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

4 of 19

2.28

3.0

1.20e-06

SM00044

Adenylyl- / guanylyl cyclase, catalytic domain

2 of 13

2.14

1.07

0.0099

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

2 of 29

1.8

0.79

0.0289

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