STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RENRenin; Belongs to the peptidase A1 family. (398 aa)    
Predicted Functional Partners:
AGT
Angiotensinogen; Belongs to the serpin family.
    
 0.819
ACE2
Angiotensin-converting enzyme.
      
 0.617
ATP6AP2
ATPase H+ transporting accessory protein 2.
   
 0.570
DRD4
Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.
      
 0.560
ins
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 0.513
ace
Angiotensin-converting enzyme.
      
 0.499
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.476
CTSH
Cathepsin H; Belongs to the peptidase C1 family.
   
 0.457
cltrn
Collectrin domain-containing protein.
      
 0.441
LOC103283025
Inhibitor_I29 domain-containing protein.
   
 0.419
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.