TRHR protein (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TRHR

Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (382 aa)

Predicted Functional Partners:

trh

0.977

LOC100562947

0.901

gnaq

0.801

GNA14

0.801

GNA11

0.801

GNA15

0.777

NTS

0.539

Edn3

0.509

EDN1

0.509

CCK

0.493

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK	EDN1	ENSACAP00000004262	ENSACAP00000008302	Cholecystokinin.	Endothelin 1.	0.402
CCK	LOC100562947	ENSACAP00000004262	ENSACAP00000017940	Cholecystokinin.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.493
CCK	NTS	ENSACAP00000004262	ENSACAP00000010944	Cholecystokinin.	Neurotensin.	0.865
CCK	TRHR	ENSACAP00000004262	ENSACAP00000010228	Cholecystokinin.	Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.493
CCK	trh	ENSACAP00000004262	ENSACAP00000023094	Cholecystokinin.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.685
EDN1	CCK	ENSACAP00000008302	ENSACAP00000004262	Endothelin 1.	Cholecystokinin.	0.402
EDN1	Edn3	ENSACAP00000008302	ENSACAP00000003605	Endothelin 1.	END domain-containing protein.	0.959
EDN1	GNA11	ENSACAP00000008302	ENSACAP00000018798	Endothelin 1.	G protein subunit alpha 11.	0.404
EDN1	GNA14	ENSACAP00000008302	ENSACAP00000018523	Endothelin 1.	G protein subunit alpha 14.	0.404
EDN1	GNA15	ENSACAP00000008302	ENSACAP00000017242	Endothelin 1.	G protein subunit alpha 15.	0.452
EDN1	LOC100562947	ENSACAP00000008302	ENSACAP00000017940	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.509
EDN1	NTS	ENSACAP00000008302	ENSACAP00000010944	Endothelin 1.	Neurotensin.	0.479
EDN1	TRHR	ENSACAP00000008302	ENSACAP00000010228	Endothelin 1.	Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.509
EDN1	gnaq	ENSACAP00000008302	ENSACAP00000005917	Endothelin 1.	Uncharacterized protein.	0.404
Edn3	EDN1	ENSACAP00000003605	ENSACAP00000008302	END domain-containing protein.	Endothelin 1.	0.959
Edn3	GNA11	ENSACAP00000003605	ENSACAP00000018798	END domain-containing protein.	G protein subunit alpha 11.	0.588
Edn3	LOC100562947	ENSACAP00000003605	ENSACAP00000017940	END domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.509
Edn3	TRHR	ENSACAP00000003605	ENSACAP00000010228	END domain-containing protein.	Thyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	0.509
GNA11	EDN1	ENSACAP00000018798	ENSACAP00000008302	G protein subunit alpha 11.	Endothelin 1.	0.404
GNA11	Edn3	ENSACAP00000018798	ENSACAP00000003605	G protein subunit alpha 11.	END domain-containing protein.	0.588