STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEURL2Neuralized E3 ubiquitin protein ligase 2. (279 aa)    
Predicted Functional Partners:
ASB5
Ankyrin repeat and SOCS box containing 5.
    
 0.674
ELOC
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
     
 0.635
CUL5
Cullin 5; Belongs to the cullin family.
     
 0.630
ELOB
Elongin B.
     
 0.597
CAND1
Cullin associated and neddylation dissociated 1.
     
 0.587
CAND2
Cullin associated and neddylation dissociated 2 (putative).
     
 0.587
CCDC22
Coiled-coil domain containing 22.
     
 0.562
CISH
Cytokine inducible SH2 containing protein.
     
 0.479
ACSS3
Acyl-CoA synthetase short chain family member 3.
      
 0.435
NAE1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
     
 0.405
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.