amh protein (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

amh

TGF_BETA_2 domain-containing protein. (410 aa)

Predicted Functional Partners:

AMHR2

0.989

BMPR2

0.949

BMPR1A

0.944

chrd

0.922

GREM2

0.903

NBL1

0.903

GREM1

0.903

DMRT1

0.858

CYP19A1

0.845

H9G412_ANOCA

0.736

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMHR2	BMPR1A	ENSACAP00000000651	ENSACAP00000014455	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
AMHR2	CYP19A1	ENSACAP00000000651	ENSACAP00000018122	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.468
AMHR2	DMRT1	ENSACAP00000000651	ENSACAP00000002280	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Doublesex and mab-3 related transcription factor 1.	0.491
AMHR2	amh	ENSACAP00000000651	ENSACAP00000015286	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.989
BMPR1A	AMHR2	ENSACAP00000014455	ENSACAP00000000651	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
BMPR1A	BMPR2	ENSACAP00000014455	ENSACAP00000004815	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.975
BMPR1A	amh	ENSACAP00000014455	ENSACAP00000015286	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.944
BMPR2	BMPR1A	ENSACAP00000004815	ENSACAP00000014455	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.975
BMPR2	amh	ENSACAP00000004815	ENSACAP00000015286	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.949
BMPR2	chrd	ENSACAP00000004815	ENSACAP00000002705	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Chordin; Belongs to the chordin family.	0.548
CYP19A1	AMHR2	ENSACAP00000018122	ENSACAP00000000651	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.468
CYP19A1	DMRT1	ENSACAP00000018122	ENSACAP00000002280	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Doublesex and mab-3 related transcription factor 1.	0.804
CYP19A1	amh	ENSACAP00000018122	ENSACAP00000015286	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	TGF_BETA_2 domain-containing protein.	0.845
DMRT1	AMHR2	ENSACAP00000002280	ENSACAP00000000651	Doublesex and mab-3 related transcription factor 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.491
DMRT1	CYP19A1	ENSACAP00000002280	ENSACAP00000018122	Doublesex and mab-3 related transcription factor 1.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.804
DMRT1	amh	ENSACAP00000002280	ENSACAP00000015286	Doublesex and mab-3 related transcription factor 1.	TGF_BETA_2 domain-containing protein.	0.858
GREM1	GREM2	ENSACAP00000015550	ENSACAP00000003598	Gremlin.	Gremlin 2, DAN family BMP antagonist.	0.902
GREM1	amh	ENSACAP00000015550	ENSACAP00000015286	Gremlin.	TGF_BETA_2 domain-containing protein.	0.903
GREM2	GREM1	ENSACAP00000003598	ENSACAP00000015550	Gremlin 2, DAN family BMP antagonist.	Gremlin.	0.902
GREM2	amh	ENSACAP00000003598	ENSACAP00000015286	Gremlin 2, DAN family BMP antagonist.	TGF_BETA_2 domain-containing protein.	0.903

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.911

expected number of edges:

18

PPI enrichment p-value:

2.2e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042254

Ribosome biogenesis

9 of 392

1.59

2.92

5.41e-10

GO:0006391

Transcription initiation from mitochondrial promoter

3 of 3

3.23

2.78

9.17e-06

GO:0042274

Ribosomal small subunit biogenesis

5 of 95

1.95

2.42

7.10e-06

GO:0006364

rRNA processing

6 of 272

1.58

1.94

1.06e-05

GO:0030490

Maturation of SSU-rRNA

3 of 49

2.02

1.31

0.0029

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034246

Mitochondrial transcription factor activity

2 of 2

3.23

1.42

0.0028

GO:0001018

Mitochondrial promoter sequence-specific DNA binding

2 of 3

3.06

1.41

0.0028

GO:0030515

snoRNA binding

3 of 39

2.12

1.34

0.0028

GO:0003723

RNA binding

10 of 1780

0.98

1.08

1.98e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030684

Preribosome

4 of 75

1.96

1.86

0.00016

GO:0042645

Mitochondrial nucleoid

3 of 43

2.08

1.6

0.00079

GO:0034388

Pwp2p-containing subcomplex of 90S preribosome

2 of 5

2.84

1.54

0.0016

GO:0030688

Preribosome, small subunit precursor

2 of 13

2.42

1.25

0.0050

GO:0032040

Small-subunit processome

2 of 36

1.98

0.84

0.0261

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15888

Mixed, incl. Small-subunit processome, and Positive regulation of rRNA processing

7 of 70

2.23

4.96

1.91e-11

CL:15903

Small-subunit processome, and Positive regulation of rRNA processing

5 of 42

2.31

3.75

2.88e-08

CL:18639

Mixed, incl. Mitochondrial transcription initiation, and Helix-hairpin-helix motif

3 of 7

2.87

2.78

7.98e-06

CL:15907

Small-subunit processome, and Positive regulation of rRNA processing

3 of 27

2.28

1.92

0.00022

CL:16011

Mixed, incl. AARP2CN (NUC121) domain, and Regulation of ribosomal subunit export from nucleus

2 of 5

2.84

1.5

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

4 of 127

1.73

1.65

0.00025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163282

Mitochondrial transcription initiation

3 of 3

3.23

3.18

1.71e-06

MAP-75944

Transcription from mitochondrial promoters

3 of 4

3.11

3.16

1.79e-06

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

7 of 426

1.45

1.92

1.71e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

7 of 441

1.43

1.9

1.71e-06

MAP-72312

rRNA processing

7 of 452

1.42

1.88

1.71e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

7 of 82

2.16

4.77

2.72e-11

GOCC:0034388

Pwp2p-containing subcomplex of 90S preribosome

3 of 7

2.87

2.75

8.98e-06

GOCC:0030686

90S preribosome

4 of 40

2.23

2.66

5.70e-06

GOCC:0030688

Preribosome, small subunit precursor

3 of 27

2.28

1.9

0.00024

GOCC:1990904

Ribonucleoprotein complex

8 of 794

1.24

1.54

1.56e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04003

Dip2/Utp12 Family

2 of 3

3.06

1.19

0.0072

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About