znf653 protein (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

znf653

Uncharacterized protein. (614 aa)

Predicted Functional Partners:

CRBN

0.577

RNF166

0.541

UBA3

0.468

NAE1

0.453

DCAF6

0.435

rab28

0.415

ECSIT

0.408

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRBN	DCAF6	ENSACAP00000005514	ENSACAP00000022442	Cereblon.	DDB1 and CUL4 associated factor 6.	0.624
CRBN	znf653	ENSACAP00000005514	ENSACAP00000016701	Cereblon.	Uncharacterized protein.	0.577
DCAF6	CRBN	ENSACAP00000022442	ENSACAP00000005514	DDB1 and CUL4 associated factor 6.	Cereblon.	0.624
DCAF6	NAE1	ENSACAP00000022442	ENSACAP00000002499	DDB1 and CUL4 associated factor 6.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.582
DCAF6	UBA3	ENSACAP00000022442	ENSACAP00000015092	DDB1 and CUL4 associated factor 6.	Ubiquitin like modifier activating enzyme 3.	0.578
DCAF6	znf653	ENSACAP00000022442	ENSACAP00000016701	DDB1 and CUL4 associated factor 6.	Uncharacterized protein.	0.435
ECSIT	znf653	ENSACAP00000016712	ENSACAP00000016701	ECSIT signalling integrator.	Uncharacterized protein.	0.408
NAE1	DCAF6	ENSACAP00000002499	ENSACAP00000022442	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	DDB1 and CUL4 associated factor 6.	0.582
NAE1	RNF166	ENSACAP00000002499	ENSACAP00000006594	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ring finger protein 166.	0.467
NAE1	UBA3	ENSACAP00000002499	ENSACAP00000015092	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin like modifier activating enzyme 3.	0.999
NAE1	znf653	ENSACAP00000002499	ENSACAP00000016701	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Uncharacterized protein.	0.453
RNF166	NAE1	ENSACAP00000006594	ENSACAP00000002499	Ring finger protein 166.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.467
RNF166	UBA3	ENSACAP00000006594	ENSACAP00000015092	Ring finger protein 166.	Ubiquitin like modifier activating enzyme 3.	0.487
RNF166	znf653	ENSACAP00000006594	ENSACAP00000016701	Ring finger protein 166.	Uncharacterized protein.	0.541
UBA3	DCAF6	ENSACAP00000015092	ENSACAP00000022442	Ubiquitin like modifier activating enzyme 3.	DDB1 and CUL4 associated factor 6.	0.578
UBA3	NAE1	ENSACAP00000015092	ENSACAP00000002499	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.999
UBA3	RNF166	ENSACAP00000015092	ENSACAP00000006594	Ubiquitin like modifier activating enzyme 3.	Ring finger protein 166.	0.487
UBA3	znf653	ENSACAP00000015092	ENSACAP00000016701	Ubiquitin like modifier activating enzyme 3.	Uncharacterized protein.	0.468
rab28	znf653	ENSACAP00000006254	ENSACAP00000016701	Uncharacterized protein.	Uncharacterized protein.	0.415
znf653	CRBN	ENSACAP00000016701	ENSACAP00000005514	Uncharacterized protein.	Cereblon.	0.577