STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHA1Pleckstrin homology domain containing A1. (202 aa)    
Predicted Functional Partners:
MYSM1
Myb like, SWIRM and MPN domains 1.
    
 0.977
LOC100554461
Uncharacterized protein.
 
   
  0.704
KDM6B
Lysine demethylase 6B.
    
 0.644
kdm6a
Uncharacterized protein.
    
 0.644
rps27a
Ubiquitin-like domain-containing protein.
   
  0.587
PTPN13
Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
    
  0.564
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.557
H2AZ1
Histone H2A; Belongs to the histone H2A family.
   
 0.557
HIST1H4J
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.531
LOC100553870
Histone H4.
   
 0.531
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.