STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)    
Predicted Functional Partners:
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.983
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.981
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.978
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.973
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.967
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.953
GLI3
GLI family zinc finger 3.
    
 0.951
GLI2
GLI family zinc finger 2.
    
 0.946
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1.
    
 0.942
ITPR2
Inositol 1,4,5-trisphosphate receptor type 2.
    
 0.942
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.