R7TIY9_CAPTE protein (Capitella teleta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

R7TIY9_CAPTE

Reelin domain-containing protein. (142 aa)

Predicted Functional Partners:

R7UB50_CAPTE

0.698

R7TJR4_CAPTE

0.691

R7TMP3_CAPTE

0.670

R7U7M9_CAPTE

0.670

R7VHV0_CAPTE

0.666

R7TXE8_CAPTE

0.661

R7TN18_CAPTE

0.659

N1PB46_CAPTE

0.651

R7TP34_CAPTE

0.648

R7UA11_CAPTE

0.648

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N1PB46_CAPTE	R7TIY9_CAPTE	N1PB46	R7TIY9	Ribosomal_L18e/L15P domain-containing protein.	Reelin domain-containing protein.	0.651
N1PB46_CAPTE	R7TJR4_CAPTE	N1PB46	R7TJR4	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL3 family.	0.998
N1PB46_CAPTE	R7TMP3_CAPTE	N1PB46	R7TMP3	Ribosomal_L18e/L15P domain-containing protein.	MRP-L46 domain-containing protein.	0.969
N1PB46_CAPTE	R7TN18_CAPTE	N1PB46	R7TN18	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein.	0.993
N1PB46_CAPTE	R7TP34_CAPTE	N1PB46	R7TP34	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein.	0.997
N1PB46_CAPTE	R7TXE8_CAPTE	N1PB46	R7TXE8	Ribosomal_L18e/L15P domain-containing protein.	Ribosomal_L16 domain-containing protein.	0.997
N1PB46_CAPTE	R7U7M9_CAPTE	N1PB46	R7U7M9	Ribosomal_L18e/L15P domain-containing protein.	MRP-L46 domain-containing protein.	0.969
N1PB46_CAPTE	R7UA11_CAPTE	N1PB46	R7UA11	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein.	0.998
N1PB46_CAPTE	R7UB50_CAPTE	N1PB46	R7UB50	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein.	0.996
N1PB46_CAPTE	R7VHV0_CAPTE	N1PB46	R7VHV0	Ribosomal_L18e/L15P domain-containing protein.	Uncharacterized protein.	0.998
R7TIY9_CAPTE	N1PB46_CAPTE	R7TIY9	N1PB46	Reelin domain-containing protein.	Ribosomal_L18e/L15P domain-containing protein.	0.651
R7TIY9_CAPTE	R7TJR4_CAPTE	R7TIY9	R7TJR4	Reelin domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL3 family.	0.691
R7TIY9_CAPTE	R7TMP3_CAPTE	R7TIY9	R7TMP3	Reelin domain-containing protein.	MRP-L46 domain-containing protein.	0.670
R7TIY9_CAPTE	R7TN18_CAPTE	R7TIY9	R7TN18	Reelin domain-containing protein.	Uncharacterized protein.	0.659
R7TIY9_CAPTE	R7TP34_CAPTE	R7TIY9	R7TP34	Reelin domain-containing protein.	Uncharacterized protein.	0.648
R7TIY9_CAPTE	R7TXE8_CAPTE	R7TIY9	R7TXE8	Reelin domain-containing protein.	Ribosomal_L16 domain-containing protein.	0.661
R7TIY9_CAPTE	R7U7M9_CAPTE	R7TIY9	R7U7M9	Reelin domain-containing protein.	MRP-L46 domain-containing protein.	0.670
R7TIY9_CAPTE	R7UA11_CAPTE	R7TIY9	R7UA11	Reelin domain-containing protein.	Uncharacterized protein.	0.648
R7TIY9_CAPTE	R7UB50_CAPTE	R7TIY9	R7UB50	Reelin domain-containing protein.	Uncharacterized protein.	0.698
R7TIY9_CAPTE	R7VHV0_CAPTE	R7TIY9	R7VHV0	Reelin domain-containing protein.	Uncharacterized protein.	0.666

page 1 of 6

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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