R7U2E7_CAPTE protein (Capitella teleta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

R7U2E7_CAPTE

DDE Tnp4 domain-containing protein. (127 aa)

Predicted Functional Partners:

R7TWV5_CAPTE

0.619

R7UZP6_CAPTE

0.539

R7V410_CAPTE

0.530

R7VCA9_CAPTE

0.530

R7TPK5_CAPTE

0.511

R7UG26_CAPTE

0.511

R7U554_CAPTE

0.489

R7VI65_CAPTE

0.488

R7TAI1_CAPTE

0.481

R7UAN5_CAPTE

0.450

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R7TAI1_CAPTE	R7U2E7_CAPTE	R7TAI1	R7U2E7	THAP-type domain-containing protein.	DDE Tnp4 domain-containing protein.	0.481
R7TPK5_CAPTE	R7U2E7_CAPTE	R7TPK5	R7U2E7	Uncharacterized protein.	DDE Tnp4 domain-containing protein.	0.511
R7TPK5_CAPTE	R7V410_CAPTE	R7TPK5	R7V410	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.920
R7TPK5_CAPTE	R7VCA9_CAPTE	R7TPK5	R7VCA9	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.920
R7TWV5_CAPTE	R7U2E7_CAPTE	R7TWV5	R7U2E7	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	DDE Tnp4 domain-containing protein.	0.619
R7TWV5_CAPTE	R7U554_CAPTE	R7TWV5	R7U554	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ubiquitin-like domain-containing protein.	0.999
R7TWV5_CAPTE	R7UAN5_CAPTE	R7TWV5	R7UAN5	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family.	0.999
R7TWV5_CAPTE	R7UZP6_CAPTE	R7TWV5	R7UZP6	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Uncharacterized protein.	0.999
R7TWV5_CAPTE	R7V410_CAPTE	R7TWV5	R7V410	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	ANK_REP_REGION domain-containing protein.	0.795
R7TWV5_CAPTE	R7VCA9_CAPTE	R7TWV5	R7VCA9	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	ANK_REP_REGION domain-containing protein.	0.795
R7U2E7_CAPTE	R7TAI1_CAPTE	R7U2E7	R7TAI1	DDE Tnp4 domain-containing protein.	THAP-type domain-containing protein.	0.481
R7U2E7_CAPTE	R7TPK5_CAPTE	R7U2E7	R7TPK5	DDE Tnp4 domain-containing protein.	Uncharacterized protein.	0.511
R7U2E7_CAPTE	R7TWV5_CAPTE	R7U2E7	R7TWV5	DDE Tnp4 domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.619
R7U2E7_CAPTE	R7U554_CAPTE	R7U2E7	R7U554	DDE Tnp4 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.489
R7U2E7_CAPTE	R7UAN5_CAPTE	R7U2E7	R7UAN5	DDE Tnp4 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family.	0.450
R7U2E7_CAPTE	R7UG26_CAPTE	R7U2E7	R7UG26	DDE Tnp4 domain-containing protein.	Uncharacterized protein.	0.511
R7U2E7_CAPTE	R7UZP6_CAPTE	R7U2E7	R7UZP6	DDE Tnp4 domain-containing protein.	Uncharacterized protein.	0.539
R7U2E7_CAPTE	R7V410_CAPTE	R7U2E7	R7V410	DDE Tnp4 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.530
R7U2E7_CAPTE	R7VCA9_CAPTE	R7U2E7	R7VCA9	DDE Tnp4 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.530
R7U2E7_CAPTE	R7VI65_CAPTE	R7U2E7	R7VI65	DDE Tnp4 domain-containing protein.	DDE Tnp4 domain-containing protein.	0.488

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.905

expected number of edges:

14

PPI enrichment p-value:

1.3e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044038

Cell wall macromolecule biosynthetic process

8 of 29

1.71

3.22

7.08e-10

GO:0009273

Peptidoglycan-based cell wall biogenesis

8 of 30

1.69

3.18

7.08e-10

GO:0071555

Cell wall organization

7 of 24

1.73

3.12

3.50e-09

GO:0009252

Peptidoglycan biosynthetic process

6 of 20

1.74

2.79

7.96e-08

GO:0051301

Cell division

7 of 32

1.61

2.67

1.57e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

4 of 8

1.97

1.94

0.00011

GO:0016874

Ligase activity

5 of 75

1.09

0.76

0.0077

GO:0043168

Anion binding

8 of 334

0.65

0.46

0.0084

GO:0036094

Small molecule binding

8 of 352

0.62

0.44

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1122

Peptidoglycan synthesis, and PASTA domain

8 of 12

2.09

5.14

6.38e-13

CL:1121

Cell cycle, and D-Alanine metabolism

9 of 21

1.9

4.64

2.12e-13

CL:1125

Peptidoglycan synthesis, and PASTA domain

4 of 6

2.09

2.58

5.50e-06

CL:1907

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lai00550

Peptidoglycan biosynthesis

7 of 17

1.88

3.76

3.21e-10

lai00473

D-Alanine metabolism

4 of 4

2.27

2.97

1.34e-06

lai01502

Vancomycin resistance

4 of 5

2.17

2.87

1.61e-06

lai00471

D-Glutamine and D-glutamate metabolism

2 of 4

1.97

1.13

0.0067

lai01503

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

1.08

0.0078

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

7 of 13

2.0

4.16

1.32e-10

KW-0573

Peptidoglycan synthesis

6 of 11

2.0

3.67

4.31e-09

KW-0132

Cell division

6 of 30

1.57

2.3

3.26e-07

KW-0131

Cell cycle

6 of 30

1.57

2.3

3.26e-07

KW-0436

Ligase

6 of 63

1.25

1.43

1.25e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 5

2.05

1.41

0.0019

PF08245

Mur ligase middle domain

3 of 6

1.97

1.39

0.0019

PF01225

Mur ligase family, catalytic domain

2 of 2

2.27

0.97

0.0158

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.05

1.18

0.0055

IPR036565

Mur-like, catalytic domain superfamily

3 of 6

1.97

1.17

0.0055

IPR013221

Mur ligase, central

3 of 6

1.97

1.17

0.0055

IPR000713

Mur ligase, N-terminal catalytic domain

2 of 2

2.27

0.8

0.0338

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About