R7U6Z6_CAPTE protein (Capitella teleta) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

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Cooccurrence

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[Homology]

Score

R7U6Z6_CAPTE

WD_REPEATS_REGION domain-containing protein. (462 aa)

Predicted Functional Partners:

R7V341_CAPTE

0.936

R7TK43_CAPTE

0.879

R7TC62_CAPTE

0.808

R7U3L5_CAPTE

0.806

R7V2A5_CAPTE

0.805

R7U252_CAPTE

0.804

R7TJ58_CAPTE

0.803

R7UK52_CAPTE

0.796

R7T9L6_CAPTE

0.790

R7TJ69_CAPTE

0.783

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R7T9L6_CAPTE	R7U6Z6_CAPTE	R7T9L6	R7U6Z6	CPSF_A domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.790
R7TC62_CAPTE	R7TJ58_CAPTE	R7TC62	R7TJ58	TFIID_20kDa domain-containing protein.	Peptidase_M1 domain-containing protein.	0.998
R7TC62_CAPTE	R7U252_CAPTE	R7TC62	R7U252	TFIID_20kDa domain-containing protein.	TAF4 domain-containing protein.	0.998
R7TC62_CAPTE	R7U3L5_CAPTE	R7TC62	R7U3L5	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.998
R7TC62_CAPTE	R7U6Z6_CAPTE	R7TC62	R7U6Z6	TFIID_20kDa domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.808
R7TC62_CAPTE	R7UK52_CAPTE	R7TC62	R7UK52	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.998
R7TC62_CAPTE	R7V2A5_CAPTE	R7TC62	R7V2A5	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.998
R7TJ58_CAPTE	R7TC62_CAPTE	R7TJ58	R7TC62	Peptidase_M1 domain-containing protein.	TFIID_20kDa domain-containing protein.	0.998
R7TJ58_CAPTE	R7U252_CAPTE	R7TJ58	R7U252	Peptidase_M1 domain-containing protein.	TAF4 domain-containing protein.	0.998
R7TJ58_CAPTE	R7U3L5_CAPTE	R7TJ58	R7U3L5	Peptidase_M1 domain-containing protein.	Uncharacterized protein.	0.998
R7TJ58_CAPTE	R7U6Z6_CAPTE	R7TJ58	R7U6Z6	Peptidase_M1 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.803
R7TJ58_CAPTE	R7UK52_CAPTE	R7TJ58	R7UK52	Peptidase_M1 domain-containing protein.	Uncharacterized protein.	0.999
R7TJ58_CAPTE	R7V2A5_CAPTE	R7TJ58	R7V2A5	Peptidase_M1 domain-containing protein.	Uncharacterized protein.	0.998
R7TJ69_CAPTE	R7U6Z6_CAPTE	R7TJ69	R7U6Z6	APC1_C domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.783
R7TK43_CAPTE	R7U6Z6_CAPTE	R7TK43	R7U6Z6	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.879
R7U252_CAPTE	R7TC62_CAPTE	R7U252	R7TC62	TAF4 domain-containing protein.	TFIID_20kDa domain-containing protein.	0.998
R7U252_CAPTE	R7TJ58_CAPTE	R7U252	R7TJ58	TAF4 domain-containing protein.	Peptidase_M1 domain-containing protein.	0.998
R7U252_CAPTE	R7U3L5_CAPTE	R7U252	R7U3L5	TAF4 domain-containing protein.	Uncharacterized protein.	0.998
R7U252_CAPTE	R7U6Z6_CAPTE	R7U252	R7U6Z6	TAF4 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.804
R7U252_CAPTE	R7UK52_CAPTE	R7U252	R7UK52	TAF4 domain-containing protein.	Uncharacterized protein.	0.998

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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