R7U9F2_CAPTE protein (Capitella teleta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

R7U9F2_CAPTE

Poly [ADP-ribose] polymerase. (329 aa)

Predicted Functional Partners:

R7V9C9_CAPTE

0.839

R7TMI9_CAPTE

0.805

R7U0Q2_CAPTE

0.801

R7U0Z1_CAPTE

0.721

R7ULS8_CAPTE

0.633

R7V6C7_CAPTE

0.633

R7TTK6_CAPTE

0.557

R7V8W6_CAPTE

0.542

R7TJR0_CAPTE

0.540

R7TSS2_CAPTE

0.539

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R7TJR0_CAPTE	R7TMI9_CAPTE	R7TJR0	R7TMI9	DEP domain-containing protein.	Uncharacterized protein.	0.996
R7TJR0_CAPTE	R7TSS2_CAPTE	R7TJR0	R7TSS2	DEP domain-containing protein.	Uncharacterized protein.	0.987
R7TJR0_CAPTE	R7U0Q2_CAPTE	R7TJR0	R7U0Q2	DEP domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.996
R7TJR0_CAPTE	R7U0Z1_CAPTE	R7TJR0	R7U0Z1	DEP domain-containing protein.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.991
R7TJR0_CAPTE	R7U9F2_CAPTE	R7TJR0	R7U9F2	DEP domain-containing protein.	Poly [ADP-ribose] polymerase.	0.540
R7TJR0_CAPTE	R7ULS8_CAPTE	R7TJR0	R7ULS8	DEP domain-containing protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.987
R7TJR0_CAPTE	R7V6C7_CAPTE	R7TJR0	R7V6C7	DEP domain-containing protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.987
R7TJR0_CAPTE	R7V8W6_CAPTE	R7TJR0	R7V8W6	DEP domain-containing protein.	Uncharacterized protein.	0.998
R7TJR0_CAPTE	R7V9C9_CAPTE	R7TJR0	R7V9C9	DEP domain-containing protein.	Zinc_ribbon_16 domain-containing protein.	0.996
R7TMI9_CAPTE	R7TJR0_CAPTE	R7TMI9	R7TJR0	Uncharacterized protein.	DEP domain-containing protein.	0.996
R7TMI9_CAPTE	R7TSS2_CAPTE	R7TMI9	R7TSS2	Uncharacterized protein.	Uncharacterized protein.	0.983
R7TMI9_CAPTE	R7U0Q2_CAPTE	R7TMI9	R7U0Q2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.997
R7TMI9_CAPTE	R7U0Z1_CAPTE	R7TMI9	R7U0Z1	Uncharacterized protein.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.996
R7TMI9_CAPTE	R7U9F2_CAPTE	R7TMI9	R7U9F2	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.805
R7TMI9_CAPTE	R7ULS8_CAPTE	R7TMI9	R7ULS8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.989
R7TMI9_CAPTE	R7V6C7_CAPTE	R7TMI9	R7V6C7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.989
R7TMI9_CAPTE	R7V8W6_CAPTE	R7TMI9	R7V8W6	Uncharacterized protein.	Uncharacterized protein.	0.996
R7TMI9_CAPTE	R7V9C9_CAPTE	R7TMI9	R7V9C9	Uncharacterized protein.	Zinc_ribbon_16 domain-containing protein.	0.997
R7TSS2_CAPTE	R7TJR0_CAPTE	R7TSS2	R7TJR0	Uncharacterized protein.	DEP domain-containing protein.	0.987
R7TSS2_CAPTE	R7TMI9_CAPTE	R7TSS2	R7TMI9	Uncharacterized protein.	Uncharacterized protein.	0.983

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.931

expected number of edges:

12

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071941

Nitrogen cycle metabolic process

3 of 13

1.85

0.91

0.0177

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

5 of 70

1.34

1.13

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2489

Multiheme cytochrome superfamily, and Nitrate assimilation

5 of 5

2.49

4.1

1.10e-08

CL:2462

Mixed, incl. Electron transport, and Immunoglobulin-like fold

6 of 19

1.99

3.51

1.10e-08

CL:2362

Mixed, incl. Oxidative phosphorylation, and Heme binding

8 of 69

1.55

2.63

5.34e-09

CL:2852

Mixed, incl. BFD-like [2Fe-2S]-binding domain, and Alkanesulfonate transport

3 of 6

2.19

1.87

0.00025

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

3 of 31

1.48

0.81

0.0184

map01120

Microbial metabolism in diverse environments

6 of 341

0.74

0.47

0.0204

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 15

1.79

1.31

0.0021

KW-0534

Nitrate assimilation

2 of 2

2.49

1.31

0.0040

KW-0408

Iron

5 of 68

1.36

1.29

0.00034

KW-0574

Periplasm

2 of 7

1.95

1.04

0.0101

KW-0500

Molybdenum

2 of 7

1.95

1.04

0.0101

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01568

Molydopterin dinucleotide binding domain

2 of 2

2.49

0.84

0.0298

PF04324

BFD-like [2Fe-2S] binding domain

2 of 3

2.31

0.83

0.0298

PF00384

Molybdopterin oxidoreductase

2 of 3

2.31

0.83

0.0298

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00926

Molybdopterin oxidoreductase Fe4S4 domain

2 of 2

2.49

1.23

0.0055

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