R7UAS7_CAPTE protein (Capitella teleta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

R7UAS7_CAPTE

Uncharacterized protein. (622 aa)

Predicted Functional Partners:

R7U4S1_CAPTE

0.763

R7U8G5_CAPTE

0.763

R7UNX7_CAPTE

0.763

R7TJS3_CAPTE

0.499

R7V6R9_CAPTE

0.477

R7UTW1_CAPTE

0.461

R7UHE1_CAPTE

0.459

R7U506_CAPTE

0.447

R7V5D5_CAPTE

0.442

R7ULM9_CAPTE

0.438

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R7TJS3_CAPTE	R7U506_CAPTE	R7TJS3	R7U506	Uncharacterized protein.	Uncharacterized protein.	0.509
R7TJS3_CAPTE	R7UAS7_CAPTE	R7TJS3	R7UAS7	Uncharacterized protein.	Uncharacterized protein.	0.499
R7TJS3_CAPTE	R7UHE1_CAPTE	R7TJS3	R7UHE1	Uncharacterized protein.	Uncharacterized protein.	0.444
R7TJS3_CAPTE	R7ULM9_CAPTE	R7TJS3	R7ULM9	Uncharacterized protein.	TSNAXIP1_N domain-containing protein.	0.415
R7TJS3_CAPTE	R7V5D5_CAPTE	R7TJS3	R7V5D5	Uncharacterized protein.	Uncharacterized protein.	0.401
R7TJS3_CAPTE	R7V6R9_CAPTE	R7TJS3	R7V6R9	Uncharacterized protein.	Uncharacterized protein.	0.409
R7U4S1_CAPTE	R7UAS7_CAPTE	R7U4S1	R7UAS7	Uncharacterized protein.	Uncharacterized protein.	0.763
R7U506_CAPTE	R7TJS3_CAPTE	R7U506	R7TJS3	Uncharacterized protein.	Uncharacterized protein.	0.509
R7U506_CAPTE	R7UAS7_CAPTE	R7U506	R7UAS7	Uncharacterized protein.	Uncharacterized protein.	0.447
R7U506_CAPTE	R7V6R9_CAPTE	R7U506	R7V6R9	Uncharacterized protein.	Uncharacterized protein.	0.425
R7U8G5_CAPTE	R7UAS7_CAPTE	R7U8G5	R7UAS7	Uncharacterized protein.	Uncharacterized protein.	0.763
R7UAS7_CAPTE	R7TJS3_CAPTE	R7UAS7	R7TJS3	Uncharacterized protein.	Uncharacterized protein.	0.499
R7UAS7_CAPTE	R7U4S1_CAPTE	R7UAS7	R7U4S1	Uncharacterized protein.	Uncharacterized protein.	0.763
R7UAS7_CAPTE	R7U506_CAPTE	R7UAS7	R7U506	Uncharacterized protein.	Uncharacterized protein.	0.447
R7UAS7_CAPTE	R7U8G5_CAPTE	R7UAS7	R7U8G5	Uncharacterized protein.	Uncharacterized protein.	0.763
R7UAS7_CAPTE	R7UHE1_CAPTE	R7UAS7	R7UHE1	Uncharacterized protein.	Uncharacterized protein.	0.459
R7UAS7_CAPTE	R7ULM9_CAPTE	R7UAS7	R7ULM9	Uncharacterized protein.	TSNAXIP1_N domain-containing protein.	0.438
R7UAS7_CAPTE	R7UNX7_CAPTE	R7UAS7	R7UNX7	Uncharacterized protein.	Uncharacterized protein.	0.763
R7UAS7_CAPTE	R7UTW1_CAPTE	R7UAS7	R7UTW1	Uncharacterized protein.	Uncharacterized protein.	0.461
R7UAS7_CAPTE	R7V5D5_CAPTE	R7UAS7	R7V5D5	Uncharacterized protein.	Uncharacterized protein.	0.442

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.818

expected number of edges:

10

PPI enrichment p-value:

2.04e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015846

Polyamine transport

4 of 4

2.32

2.47

1.80e-05

GO:0055085

Transmembrane transport

8 of 245

0.84

0.73

0.00030

GO:0006810

Transport

9 of 296

0.8

0.71

0.00022

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015417

ABC-type polyamine transporter activity

4 of 4

2.32

2.6

9.59e-06

GO:0015594

ABC-type putrescine transporter activity

3 of 3

2.32

1.89

0.00027

GO:0140359

ABC-type transporter activity

5 of 46

1.36

1.32

0.00027

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

4 of 20

1.62

1.56

0.00027

GO:0005886

Plasma membrane

8 of 387

0.64

0.51

0.00094

GO:0016021

Integral component of membrane

8 of 443

0.58

0.45

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3114

Polyamine transport, and MetI-like superfamily

10 of 12

2.24

7.39

2.45e-18

CL:3112

Mixed, incl. MetI-like superfamily, and Polyamine transport

11 of 27

1.93

5.87

2.45e-18

CL:3116

ABC-type polyamine transporter activity, and ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

5 of 5

2.32

3.86

1.79e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

7 of 194

0.88

0.73

0.00087

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

4 of 34

1.39

1.03

0.0037

GOCC:0016021

Integral component of membrane

5 of 79

1.12

0.85

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

6 of 89

1.15

1.09

0.00026

KW-1003

Cell membrane

5 of 104

1.0

0.72

0.0063

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

4 of 19

1.65

1.41

0.00080

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035906

MetI-like superfamily

4 of 19

1.65

1.25

0.0021

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

4 of 19

1.65

1.25

0.0021

IPR015853

ABC transporter, ferric cation import, FbpC

2 of 2

2.32

0.78

0.0372

IPR008995

Molybdate/tungstate binding, C-terminal

2 of 3

2.15

0.72

0.0464

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