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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AOP35726.1Cobalamin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)    
Predicted Functional Partners:
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
       0.833
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
 
  
 0.709
AOP35871.1
TonB-dependent receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.629
AOP35725.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.580
AOP36540.1
Cobalamin biosynthesis protein CobQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.579
folE
GTP cyclohydrolase I FolE; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.576
AOP35724.1
Cysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.558
AOP36529.1
precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.524
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
   
   0.503
hisE
phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.503
Your Current Organism:
Leptospira alstonii
NCBI taxonomy Id: 28452
Other names: ATCC BAA-2439, L. alstonii, Leptospira alstoni, Leptospira alstonii Smythe et al. 2013, Leptospira genomosp. 1, strain 79601
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