node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDF65852.1 | SDF68816.1 | SAMN05216571_10186 | SAMN05216571_101219 | Threonine dehydratase. | Phosphoserine phosphatase. | 0.923 |
SDF65852.1 | SDF85965.1 | SAMN05216571_10186 | SAMN05216571_102337 | Threonine dehydratase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.926 |
SDF65852.1 | SDG58046.1 | SAMN05216571_10186 | SAMN05216571_12139 | Threonine dehydratase. | Homoserine dehydrogenase. | 0.640 |
SDF65852.1 | glyA | SAMN05216571_10186 | SAMN05216571_101142 | Threonine dehydratase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
SDF65852.1 | glyA-2 | SAMN05216571_10186 | SAMN05216571_102355 | Threonine dehydratase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
SDF65852.1 | ilvA | SAMN05216571_10186 | SAMN05216571_105115 | Threonine dehydratase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.925 |
SDF65852.1 | trpA | SAMN05216571_10186 | SAMN05216571_1072 | Threonine dehydratase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.893 |
SDF65852.1 | trpA-2 | SAMN05216571_10186 | SAMN05216571_1166 | Threonine dehydratase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.893 |
SDF68816.1 | SDF65852.1 | SAMN05216571_101219 | SAMN05216571_10186 | Phosphoserine phosphatase. | Threonine dehydratase. | 0.923 |
SDF68816.1 | SDF85965.1 | SAMN05216571_101219 | SAMN05216571_102337 | Phosphoserine phosphatase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.946 |
SDF68816.1 | SDF86366.1 | SAMN05216571_101219 | SAMN05216571_102358 | Phosphoserine phosphatase. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.457 |
SDF68816.1 | SDG23910.1 | SAMN05216571_101219 | SAMN05216571_10715 | Phosphoserine phosphatase. | Serine O-acetyltransferase. | 0.971 |
SDF68816.1 | SDG58046.1 | SAMN05216571_101219 | SAMN05216571_12139 | Phosphoserine phosphatase. | Homoserine dehydrogenase. | 0.860 |
SDF68816.1 | glyA | SAMN05216571_101219 | SAMN05216571_101142 | Phosphoserine phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
SDF68816.1 | glyA-2 | SAMN05216571_101219 | SAMN05216571_102355 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
SDF68816.1 | ilvA | SAMN05216571_101219 | SAMN05216571_105115 | Phosphoserine phosphatase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
SDF68816.1 | trpA | SAMN05216571_101219 | SAMN05216571_1072 | Phosphoserine phosphatase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |
SDF68816.1 | trpA-2 | SAMN05216571_101219 | SAMN05216571_1166 | Phosphoserine phosphatase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |
SDF85965.1 | SDF65852.1 | SAMN05216571_102337 | SAMN05216571_10186 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase. | 0.926 |
SDF85965.1 | SDF68816.1 | SAMN05216571_102337 | SAMN05216571_101219 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.946 |