node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDF73855.1 | SDF73881.1 | SAMN05216571_101464 | SAMN05216571_101465 | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
SDF73855.1 | cobB | SAMN05216571_101464 | SAMN05216571_10747 | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | 0.916 |
SDF73855.1 | nadE | SAMN05216571_101464 | SAMN05216571_11112 | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.924 |
SDF73855.1 | nadK | SAMN05216571_101464 | SAMN05216571_101439 | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.934 |
SDF73855.1 | sthA | SAMN05216571_101464 | SAMN05216571_103327 | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | NAD(P) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.918 |
SDF73881.1 | SDF73855.1 | SAMN05216571_101465 | SAMN05216571_101464 | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.999 |
SDF73881.1 | SDG05122.1 | SAMN05216571_101465 | SAMN05216571_1044 | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | ATP diphosphatase. | 0.914 |
SDF73881.1 | nadE | SAMN05216571_101465 | SAMN05216571_11112 | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.945 |
SDF73881.1 | nadK | SAMN05216571_101465 | SAMN05216571_101439 | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.958 |
SDF73881.1 | sthA | SAMN05216571_101465 | SAMN05216571_103327 | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.919 |
SDF83781.1 | SDF92436.1 | SAMN05216571_102236 | SAMN05216571_10318 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | 0.998 |
SDF83781.1 | SDG29152.1 | SAMN05216571_102236 | SAMN05216571_108113 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoglutarate dehydrogenase E1 component. | 0.996 |
SDF83781.1 | sthA | SAMN05216571_102236 | SAMN05216571_103327 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | NAD(P) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.911 |
SDF92436.1 | SDF83781.1 | SAMN05216571_10318 | SAMN05216571_102236 | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.998 |
SDF92436.1 | SDG29133.1 | SAMN05216571_10318 | SAMN05216571_108112 | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.998 |
SDF92436.1 | SDG29152.1 | SAMN05216571_10318 | SAMN05216571_108113 | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | 2-oxoglutarate dehydrogenase E1 component. | 0.927 |
SDF92436.1 | sthA | SAMN05216571_10318 | SAMN05216571_103327 | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | NAD(P) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.981 |
SDG05122.1 | SDF73881.1 | SAMN05216571_1044 | SAMN05216571_101465 | ATP diphosphatase. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.914 |
SDG05122.1 | sthA | SAMN05216571_1044 | SAMN05216571_103327 | ATP diphosphatase. | NAD(P) transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.915 |
SDG29133.1 | SDF92436.1 | SAMN05216571_108112 | SAMN05216571_10318 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 2-oxoisovalerate dehydrogenase E1 component beta subunit. | 0.998 |