| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KOO40697.1 | KOO45916.1 | AMD01_20540 | AMD01_12635 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.469 |
| KOO40697.1 | KOO46096.1 | AMD01_20540 | AMD01_09480 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.428 |
| KOO40697.1 | KOO50534.1 | AMD01_20540 | AMD01_01935 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.737 |
| KOO40697.1 | KOO50791.1 | AMD01_20540 | AMD01_03375 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.431 |
| KOO40697.1 | fmt | AMD01_20540 | AMD01_20545 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.999 |
| KOO40697.1 | thyA | AMD01_20540 | AMD01_03370 | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.881 |
| KOO41117.1 | tdk | AMD01_19420 | AMD01_22775 | 2,' 3'-cyclic nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. | Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.787 |
| KOO41117.1 | thyA | AMD01_19420 | AMD01_03370 | 2,' 3'-cyclic nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.769 |
| KOO41117.1 | tmk | AMD01_19420 | AMD01_18515 | 2,' 3'-cyclic nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.774 |
| KOO45916.1 | KOO40697.1 | AMD01_12635 | AMD01_20540 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.469 |
| KOO45916.1 | rnhB | AMD01_12635 | AMD01_12500 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.909 |
| KOO45916.1 | thyA | AMD01_12635 | AMD01_03370 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.767 |
| KOO46096.1 | KOO40697.1 | AMD01_09480 | AMD01_20540 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.428 |
| KOO46096.1 | KOO50534.1 | AMD01_09480 | AMD01_01935 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.841 |
| KOO46096.1 | fmt | AMD01_09480 | AMD01_20545 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.624 |
| KOO46096.1 | tdk | AMD01_09480 | AMD01_22775 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.661 |
| KOO46096.1 | thyA | AMD01_09480 | AMD01_03370 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.894 |
| KOO46096.1 | tmk | AMD01_09480 | AMD01_18515 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.630 |
| KOO50534.1 | KOO40697.1 | AMD01_01935 | AMD01_20540 | Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. | 16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.737 |
| KOO50534.1 | KOO46096.1 | AMD01_01935 | AMD01_09480 | Homocysteine methyltransferase; Catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.841 |