STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLLA0_E16897gKLLA0E16897p; Belongs to the ClpA/ClpB family. (825 aa)    
Predicted Functional Partners:
KLLA0_F18194g
KLLA0F18194p.
  
 
 
0.978
mge1
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins (By similarity).
  
 
 0.857
KLLA0_E24597g
KLLA0E24597p.
  
 
 0.765
KLLA0_D17446g
KLLA0D17446p; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.754
KLLA0_A07062g
KLLA0A07062p.
   
 
 0.728
SSB1
Ribosome-associated molecular chaperone SSB1; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...]
  
 
 0.727
KLLA0_D07656g
KLLA0D07656p.
  
 
 0.724
KLLA0_D04818g
KLLA0D04818p.
  
 
 0.720
KLLA0_E22309g
KLLA0E22309p; Belongs to the heat shock protein 70 family.
  
 
 0.719
KLLA0_F18909g
KLLA0F18909p; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.718
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.