STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLLA0_C09823gKLLA0C09823p. (669 aa)    
Predicted Functional Partners:
KLLA0_E24553g
KLLA0E24553p.
    
 0.995
SEC62
Translocation protein SEC62; Required for preprotein translocation.
   
 0.995
KLLA0_C05104g
KLLA0C05104p.
    
 0.995
SEC61
Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
   
 0.984
KLLA0_C11957g
KLLA0C11957p.
    
 0.955
SBH1
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
    
 0.929
KLLA0_F02057g
KLLA0F02057p; Belongs to the SecY/SEC61-alpha family.
   
 0.887
GRP78
Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family.
  
 
 0.868
KLLA0_F26455g
KLLA0F26455p.
  
 
 0.687
KLLA0_B10197g
KLLA0B10197p.
   
 
 0.654
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.