STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIM21pH-response regulator protein palH/RIM21; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palH/RIM21 family. (519 aa)    
Predicted Functional Partners:
RIM8
pH-response regulator protein palF/RIM8; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
    
 
 0.889
RIM13
Calpain-like protease palB/RIM13; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
   
 
 0.842
RIM101
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family.
   
 
 0.825
KLLA0_E16831g
KLLA0E16831p.
    
 
 0.616
RIM20
pH-response regulator protein palA/RIM20; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity); Belongs to the palA/RIM20 family.
    
 
 0.591
SNF7
Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
    
 
 0.583
PPN1
Endopolyphosphatase; Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
   
  
 0.565
PALI2_KLULA
pH-response regulator palI/RIM9 homolog 2; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palI/RIM9 family.
    
 
 0.468
PALI1_KLULA
pH-response regulator palI/RIM9 homolog 1; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palI/RIM9 family.
    
 
 0.468
KEX1
Protease KEX1; Probably involved in the processing of the precursor of m1- toxin and alpha-factor.
   
 0.442
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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