STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMLALPHA2Mating-type protein ALPHA2; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with A1 to repress transcription of haploid-specific genes (By similarity); Belongs to the TALE/M-ATYP homeobox family. (223 aa)    
Predicted Functional Partners:
KLLA0_A02629g
KLLA0A02629p.
    
 0.911
MATA2
Mating-type protein A2; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific genes (By similarity).
   
  
 0.679
HMLALPHA3
Mating-type protein ALPHA3; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for efficient mating as an alpha-cell.
   
 
 0.670
KLLA0_F26807g
KLLA0F26807p.
   
 
 0.663
MATA1
Mating-type protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription of haploid-specific genes (By similarity). Belongs to the MATA1 family.
   
 
 0.661
CDC123
Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family.
   
  
 0.585
STE12
Protein STE12; Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in the mating process (By similarity).
   
 
 0.583
SIR2
NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase, which asts as a key regulator of gene expression believed to help form modified chromatin structures on the genes it regulates. It is involved in telomeric silencing and in hm mating type loci silencing (By similarity); Belongs to the sirtuin family. Class I subfamily.
      
 0.573
DYN3
Cytoplasmic dynein intermediate light chain DYN3; Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle (By similarity).
   
  
 0.562
KLLA0_B00759g
KLLA0B00759p; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.461
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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