node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUR2 | HOT1 | Q6CK68 | Q6CR76 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | 0.579 |
BUR2 | KLLA0_C06160g | Q6CK68 | Q6CUB7 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | KLLA0C06160p. | 0.680 |
BUR2 | KLLA0_D01595g | Q6CK68 | Q6CSE9 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | 0.803 |
BUR2 | KLLA0_F09361g | Q6CK68 | Q6CKN3 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | KLLA0F09361p. | 0.750 |
HOG1 | HOT1 | Q6CJA8 | Q6CR76 | Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | 0.970 |
HOT1 | BUR2 | Q6CR76 | Q6CK68 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | 0.579 |
HOT1 | HOG1 | Q6CR76 | Q6CJA8 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. | 0.970 |
HOT1 | IWS1 | Q6CR76 | Q6CVL1 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | 0.579 |
HOT1 | KLLA0_B06138g | Q6CR76 | Q6CW79 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | KLLA0B06138p. | 0.673 |
HOT1 | KLLA0_C06160g | Q6CR76 | Q6CUB7 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | KLLA0C06160p. | 0.589 |
HOT1 | KLLA0_D01595g | Q6CR76 | Q6CSE9 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | 0.584 |
HOT1 | KLLA0_E11793g | Q6CR76 | Q6CNK7 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | KLLA0E11793p. | 0.719 |
HOT1 | KLLA0_F09361g | Q6CR76 | Q6CKN3 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | KLLA0F09361p. | 0.627 |
HOT1 | RPB5 | Q6CR76 | Q6CJ62 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] | 0.577 |
HOT1 | SPT6 | Q6CR76 | Q6CVK3 | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. | 0.575 |
IWS1 | HOT1 | Q6CVL1 | Q6CR76 | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | High-osmolarity-induced transcription protein 1; Required for a complete transcriptional response to osmotic stress; Belongs to the HOT1 family. | 0.579 |
IWS1 | KLLA0_C06160g | Q6CVL1 | Q6CUB7 | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | KLLA0C06160p. | 0.696 |
IWS1 | KLLA0_D01595g | Q6CVL1 | Q6CSE9 | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | 0.969 |
IWS1 | KLLA0_F09361g | Q6CVL1 | Q6CKN3 | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | KLLA0F09361p. | 0.984 |
IWS1 | RPB5 | Q6CVL1 | Q6CJ62 | Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. | DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] | 0.650 |