STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PFA3Palmitoyltransferase PFA3; Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity). (325 aa)    
Predicted Functional Partners:
VAC8
Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family.
   
 
 0.827
AKR1
Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
   
 
 0.802
GAL1
Galactokinase; Seems bifunctional with both a galactokinase activity and the ability to induce the GAL genes; Belongs to the GHMP kinase family. GalK subfamily.
   
  
 0.610
SWF1
Palmitoyltransferase SWF1; Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity); Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
  
  
0.585
TOF1
Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
   
 
 0.504
CSM3
Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
   
 
 0.503
PFA4
Palmitoyltransferase PFA4; Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function; Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
  
   
0.464
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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