STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIG1Regulatory protein MIG1; Involved in glucose repression of glucose metabolism genes; Belongs to the creA/MIG C2H2-type zinc-finger protein family. (474 aa)    
Predicted Functional Partners:
KLLA0_A03806g
Non-specific serine/threonine protein kinase.
    
 0.873
TUP1
General transcriptional corepressor TUP1; Represses transcription by RNA polymerase II.
   
 0.867
KLLA0_B09262g
KLLA0B09262p.
   
 0.722
RIM101
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family.
    
 
 0.653
RAG5
Hexokinase; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Has higher affinity for D-glucose. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate ; Belongs to the hexokinase family.
    
 
 0.617
LAC12
Lactose permease; LAC12 mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
   
 
 0.614
KLLA0_E20351g
Ubiquitin carboxyl-terminal hydrolase.
    
 
 0.606
SNF4
5'-AMP-activated protein kinase subunit gamma; Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer- term effects via phosphorylation of transcription regulators [...]
   
 0.586
RAG1
Low-affinity glucose transporter; Low-affinity glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
    
 
 0.579
GSM1
Glucose starvation modulator protein 1; Transcription factor which regulates nonfermentable carbon utilization; Belongs to the ERT1/acuK family.
   
 
 0.574
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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