STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPC42Spindle pole body component SPC42; Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane; Belongs to the SPC42 family. (316 aa)    
Predicted Functional Partners:
BBP1
Spindle pole component BBP1; Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity).
   
 
 0.786
MPS2
Monopolar spindle protein 2; Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication; Belongs to the MPS2 family.
   
 
 0.716
SPC29
Spindle pole component 29; Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity); Belongs to the SPC29 family.
   
  
 0.685
CMD1
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
    
 
 0.661
LTE1
Guanine nucleotide exchange factor LTE1; GDP-GTP exchange factor component of the mitotic exit network (MEN). Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis. May also be involved in proprotein-processing in the secretory pathway (By similarity); Belongs to the LTE1 family.
      
 0.650
KLLA0_B03498g
KLLA0B03498p.
    
 
 0.632
KLLA0_A03509g
KLLA0A03509p.
    
 
 0.563
SUP35
Eukaryotic peptide chain release factor GTP-binding subunit; Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
      
 0.551
KLLA0_D15136g
KLLA0D15136p.
      
 0.550
KLLA0_D19580g
KLLA0D19580p.
    
 
 0.549
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.