STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SNF45'-AMP-activated protein kinase subunit gamma; Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer- term effects via phosphorylation of transcription regulators [...] (328 aa)    
Predicted Functional Partners:
KLLA0_B00583g
KLLA0B00583p.
   
 0.999
KLLA0_A03806g
Non-specific serine/threonine protein kinase.
   
 0.998
KLLA0_B13948g
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.964
KLLA0_A09471g
KLLA0A09471p.
    
 0.961
KLLA0_F19536g
Non-specific serine/threonine protein kinase.
   
 0.899
KLLA0_F11319g
KLLA0F11319p.
   
 0.899
KLLA0_D08184g
KLLA0D08184p.
   
 0.868
ATG1
Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...]
    
 0.797
KLLA0_D09328g
KLLA0D09328p.
   
 0.774
KLLA0_A11330g
KLLA0A11330p.
 
 
 0.718
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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