node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MUS81 | Q6FIZ6_CANGA | Q6FYA6 | Q6FIZ6 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | RECA_2 domain-containing protein. | 0.864 |
MUS81 | Q6FLV3_CANGA | Q6FYA6 | Q6FLV3 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | Uncharacterized protein. | 0.886 |
MUS81 | Q6FNS1_CANGA | Q6FYA6 | Q6FNS1 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | ERCC4 domain-containing protein. | 0.933 |
MUS81 | Q6FNS3_CANGA | Q6FYA6 | Q6FNS3 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | RMI1_N domain-containing protein. | 0.953 |
MUS81 | Q6FQZ6_CANGA | Q6FYA6 | Q6FQZ6 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | Uncharacterized protein. | 0.854 |
MUS81 | Q6FRJ4_CANGA | Q6FYA6 | Q6FRJ4 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | Uncharacterized protein. | 0.894 |
MUS81 | Q6FSG2_CANGA | Q6FYA6 | Q6FSG2 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.885 |
MUS81 | Q6FSR2_CANGA | Q6FYA6 | Q6FSR2 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.951 |
MUS81 | RFA1 | Q6FYA6 | Q6FTQ0 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.898 |
MUS81 | SLX1 | Q6FYA6 | Q6FML9 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.953 |
Q6FIZ6_CANGA | MUS81 | Q6FIZ6 | Q6FYA6 | RECA_2 domain-containing protein. | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. | 0.864 |
Q6FIZ6_CANGA | Q6FLV3_CANGA | Q6FIZ6 | Q6FLV3 | RECA_2 domain-containing protein. | Uncharacterized protein. | 0.890 |
Q6FIZ6_CANGA | Q6FNS1_CANGA | Q6FIZ6 | Q6FNS1 | RECA_2 domain-containing protein. | ERCC4 domain-containing protein. | 0.699 |
Q6FIZ6_CANGA | Q6FNS3_CANGA | Q6FIZ6 | Q6FNS3 | RECA_2 domain-containing protein. | RMI1_N domain-containing protein. | 0.803 |
Q6FIZ6_CANGA | Q6FQZ6_CANGA | Q6FIZ6 | Q6FQZ6 | RECA_2 domain-containing protein. | Uncharacterized protein. | 0.856 |
Q6FIZ6_CANGA | Q6FRJ4_CANGA | Q6FIZ6 | Q6FRJ4 | RECA_2 domain-containing protein. | Uncharacterized protein. | 0.883 |
Q6FIZ6_CANGA | Q6FSG2_CANGA | Q6FIZ6 | Q6FSG2 | RECA_2 domain-containing protein. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.889 |
Q6FIZ6_CANGA | Q6FSR2_CANGA | Q6FIZ6 | Q6FSR2 | RECA_2 domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.849 |
Q6FIZ6_CANGA | RFA1 | Q6FIZ6 | Q6FTQ0 | RECA_2 domain-containing protein. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.795 |
Q6FIZ6_CANGA | SLX1 | Q6FIZ6 | Q6FML9 | RECA_2 domain-containing protein. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.665 |