node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG8 | FIS1 | Q6FXR8 | Q6FIQ1 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] | Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). | 0.579 |
ATG8 | GYP7 | Q6FXR8 | Q6FWI1 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | 0.981 |
ATG8 | Q6FVE2_CANGA | Q6FXR8 | Q6FVE2 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] | Uncharacterized protein. | 0.715 |
FIS1 | ATG8 | Q6FIQ1 | Q6FXR8 | Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] | 0.579 |
FIS1 | GYP7 | Q6FIQ1 | Q6FWI1 | Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | 0.605 |
GYP7 | ATG8 | Q6FWI1 | Q6FXR8 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] | 0.981 |
GYP7 | FIS1 | Q6FWI1 | Q6FIQ1 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). | 0.605 |
GYP7 | INP53 | Q6FWI1 | Q6FXM3 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | SAC domain-containing protein. | 0.663 |
GYP7 | Q6FLX7_CANGA | Q6FWI1 | Q6FLX7 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Uncharacterized protein. | 0.719 |
GYP7 | Q6FPP6_CANGA | Q6FWI1 | Q6FPP6 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | SAC domain-containing protein. | 0.631 |
GYP7 | Q6FSU4_CANGA | Q6FWI1 | Q6FSU4 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Uncharacterized protein. | 0.589 |
GYP7 | Q6FT79_CANGA | Q6FWI1 | Q6FT79 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | SAC domain-containing protein. | 0.665 |
GYP7 | Q6FUB2_CANGA | Q6FWI1 | Q6FUB2 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Uncharacterized protein. | 0.638 |
GYP7 | Q6FVE2_CANGA | Q6FWI1 | Q6FVE2 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Uncharacterized protein. | 0.987 |
GYP7 | SEC4 | Q6FWI1 | O42819 | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | Ras-related protein SEC4; Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.724 |
INP53 | GYP7 | Q6FXM3 | Q6FWI1 | SAC domain-containing protein. | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | 0.663 |
INP53 | Q6FPP6_CANGA | Q6FXM3 | Q6FPP6 | SAC domain-containing protein. | SAC domain-containing protein. | 0.950 |
INP53 | Q6FT79_CANGA | Q6FXM3 | Q6FT79 | SAC domain-containing protein. | SAC domain-containing protein. | 0.908 |
Q6FLX7_CANGA | GYP7 | Q6FLX7 | Q6FWI1 | Uncharacterized protein. | GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). | 0.719 |
Q6FLX7_CANGA | Q6FUB2_CANGA | Q6FLX7 | Q6FUB2 | Uncharacterized protein. | Uncharacterized protein. | 0.831 |