STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GYP7GTPase-activating protein GYP7; Most effectively accelerate the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and YPT1. YPT6 and SEC4 (By similarity). (745 aa)    
Predicted Functional Partners:
Q6FVE2_CANGA
Uncharacterized protein.
   
 0.987
ATG8
Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...]
   
 0.981
SEC4
Ras-related protein SEC4; Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity); Belongs to the small GTPase superfamily. Rab family.
   
 0.724
Q6FLX7_CANGA
Uncharacterized protein.
     
 0.719
Q6FT79_CANGA
SAC domain-containing protein.
      
 0.665
INP53
SAC domain-containing protein.
      
 0.663
Q6FUB2_CANGA
Uncharacterized protein.
   
 0.638
Q6FPP6_CANGA
SAC domain-containing protein.
      
 0.631
FIS1
Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
    
 
 0.605
Q6FSU4_CANGA
Uncharacterized protein.
   
  
 0.589
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
Server load: low (18%) [HD]