node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASF1 | CSE4 | Q6FL84 | Q874J6 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | 0.867 |
ASF1 | HHF1 | Q6FL84 | Q8NIG3 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | 0.994 |
ASF1 | HHT1 | Q6FL84 | P61833 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.886 |
ASF1 | Q6FJL8_CANGA | Q6FL84 | Q6FJL8 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | WD_REPEATS_REGION domain-containing protein. | 0.626 |
ASF1 | Q6FN62_CANGA | Q6FL84 | Q6FN62 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | Uncharacterized protein. | 0.889 |
ASF1 | Q6FP55_CANGA | Q6FL84 | Q6FP55 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | WD_REPEATS_REGION domain-containing protein. | 0.994 |
ASF1 | RTT106 | Q6FL84 | Q6FRJ6 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). | 0.720 |
ASF1 | SPT16 | Q6FL84 | Q6FWT4 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.550 |
CSE4 | ASF1 | Q874J6 | Q6FL84 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | 0.867 |
CSE4 | HHF1 | Q874J6 | Q8NIG3 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | 0.974 |
CSE4 | HHT1 | Q874J6 | P61833 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.593 |
CSE4 | Q6FJL8_CANGA | Q874J6 | Q6FJL8 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | WD_REPEATS_REGION domain-containing protein. | 0.610 |
CSE4 | Q6FN62_CANGA | Q874J6 | Q6FN62 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | Uncharacterized protein. | 0.440 |
CSE4 | Q6FP55_CANGA | Q874J6 | Q6FP55 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | WD_REPEATS_REGION domain-containing protein. | 0.786 |
CSE4 | RTT106 | Q874J6 | Q6FRJ6 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). | 0.662 |
CSE4 | SPT16 | Q874J6 | Q6FWT4 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.831 |
HHF1 | ASF1 | Q8NIG3 | Q6FL84 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | 0.994 |
HHF1 | CSE4 | Q8NIG3 | Q874J6 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). | 0.974 |
HHF1 | HHT1 | Q8NIG3 | P61833 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.999 |
HHF1 | Q6FJL8_CANGA | Q8NIG3 | Q6FJL8 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | WD_REPEATS_REGION domain-containing protein. | 0.878 |